2tob

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[[Image:2tob.gif|left|200px]]
[[Image:2tob.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2tob |SIZE=350|CAPTION= <scene name='initialview01'>2tob</scene>
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The line below this paragraph, containing "STRUCTURE_2tob", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2TB:1,3-DIAMINO-4,5,6-TRIHYDROXY-CYCLOHEXANE'>2TB</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=TOA:3-DEOXY-3-AMINO+GLUCOSE'>TOA</scene>, <scene name='pdbligand=TOC:2,3,6-TRIDEOXY-2,6-DIAMINO+GLUCOSE'>TOC</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2tob| PDB=2tob | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2tob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tob OCA], [http://www.ebi.ac.uk/pdbsum/2tob PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2tob RCSB]</span>
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}}
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'''SOLUTION STRUCTURE OF THE TOBRAMYCIN-RNA APTAMER COMPLEX, NMR, 13 STRUCTURES'''
'''SOLUTION STRUCTURE OF THE TOBRAMYCIN-RNA APTAMER COMPLEX, NMR, 13 STRUCTURES'''
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==About this Structure==
==About this Structure==
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2TOB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TOB OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TOB OCA].
==Reference==
==Reference==
Solution structure of the tobramycin-RNA aptamer complex., Jiang L, Patel DJ, Nat Struct Biol. 1998 Sep;5(9):769-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9731769 9731769]
Solution structure of the tobramycin-RNA aptamer complex., Jiang L, Patel DJ, Nat Struct Biol. 1998 Sep;5(9):769-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9731769 9731769]
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[[Category: Protein complex]]
 
[[Category: Jiang, L.]]
[[Category: Jiang, L.]]
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
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[[Category: aminoglycoside-rna recognition]]
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[[Category: Aminoglycoside-rna recognition]]
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[[Category: tobramycin]]
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[[Category: Tobramycin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:25:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:54 2008''
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Revision as of 14:25, 4 May 2008

Image:2tob.gif

Template:STRUCTURE 2tob

SOLUTION STRUCTURE OF THE TOBRAMYCIN-RNA APTAMER COMPLEX, NMR, 13 STRUCTURES


Overview

We have solved the solution structure of the aminoglycoside antibiotic tobramycin complexed with a stem-loop RNA aptamer. The 14 base loop of the RNA aptamer 'zippers up' alongside the attached stem through alignment of four mismatches and one Watson-Crick pair on complex formation. The tobramycin inserts into the deep groove centered about the mismatch pairs and is partially encapsulated between its floor and a looped out guanine base that flaps over the bound antibiotic. Several potential intermolecular hydrogen bonds between the charged NH3 groups of tobramycin and acceptor atoms on base pair edges and backbone phosphates anchor the aminoglycoside antibiotic within its sequence/structure specific RNA binding pocket.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of the tobramycin-RNA aptamer complex., Jiang L, Patel DJ, Nat Struct Biol. 1998 Sep;5(9):769-74. PMID:9731769 Page seeded by OCA on Sun May 4 17:25:15 2008

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