6ht9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Mouse fetuin-B in complex with crayfish astacin== | |
| - | + | <StructureSection load='6ht9' size='340' side='right'caption='[[6ht9]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ht9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HT9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Astacin Astacin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ht9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht9 OCA], [http://pdbe.org/6ht9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ht9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ht9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS]] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. [[http://www.uniprot.org/uniprot/FETUB_MOUSE FETUB_MOUSE]] Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.<ref>PMID:23562279</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Astacin]] | ||
| + | [[Category: Astacus astacus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cuppari, A]] | ||
| + | [[Category: Gomis-Ruth, F X]] | ||
| + | [[Category: Goulas, T]] | ||
| + | [[Category: Guevara, T]] | ||
| + | [[Category: Cystatin]] | ||
| + | [[Category: Fetuin]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Metallopeptidase]] | ||
| + | [[Category: Ovastacin inhibitor]] | ||
| + | [[Category: Peptidase inhibitor]] | ||
Revision as of 12:02, 13 March 2019
Mouse fetuin-B in complex with crayfish astacin
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