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6hzy

From Proteopedia

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'''Unreleased structure'''
 
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The entry 6hzy is ON HOLD
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==Crystal structure of a bacterial fucosidase with inhibitor FucPUG==
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<StructureSection load='6hzy' size='340' side='right' caption='[[6hzy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hzy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HZY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GYZ:[(~{Z})-[(3~{S},4~{R},5~{S},6~{S})-6-methyl-3,4,5-tris(oxidanyl)oxan-2-ylidene]amino]+~{N}-phenylcarbamate'>GYZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hzy OCA], [http://pdbe.org/6hzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hzy RCSB], [http://www.ebi.ac.uk/pdbsum/6hzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hzy ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, alpha-L-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel alpha-L-fucosidase inhibitors, with X-ray crystallographic analysis using an alpha-L-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.
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Authors:
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Synthetic and crystallographic insight into exploiting sp2-hybridization in the development of alpha-L-fucosidase inhibitors.,Coyle T, Wu L, Debowski A, Davies G, Stubbs KA Chembiochem. 2019 Jan 21. doi: 10.1002/cbic.201800710. PMID:30663832<ref>PMID:30663832</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6hzy" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Coyle, T]]
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[[Category: Davies, G J]]
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[[Category: Debowski, A W]]
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[[Category: Stubbs, K A]]
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[[Category: Wu, L]]
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[[Category: Hydrolase]]

Revision as of 06:46, 21 February 2019

Crystal structure of a bacterial fucosidase with inhibitor FucPUG

6hzy, resolution 1.70Å

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