6mok

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'''Unreleased structure'''
 
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The entry 6mok is ON HOLD until Paper Publication
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==Dimeric DARPin ANR7 complex with EpoR==
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<StructureSection load='6mok' size='340' side='right'caption='[[6mok]], [[Resolution|resolution]] 5.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mok]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MOK FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mok OCA], [http://pdbe.org/6mok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mok RCSB], [http://www.ebi.ac.uk/pdbsum/6mok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mok ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/EPOR_HUMAN EPOR_HUMAN]] Defects in EPOR are the cause of familial erythrocytosis type 1 (ECYT1) [MIM:[http://omim.org/entry/133100 133100]]. ECYT1 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia.<ref>PMID:8506290</ref> <ref>PMID:8174675</ref> <ref>PMID:8608241</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/EPOR_HUMAN EPOR_HUMAN]] Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Garcia, K C]]
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[[Category: Guo, Y]]
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[[Category: Jude, K M]]
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[[Category: Mohan, K]]
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[[Category: Biosynthetic protein]]
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[[Category: Complex]]
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[[Category: Darpin]]
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[[Category: Receptor]]

Revision as of 22:48, 5 June 2019

Dimeric DARPin ANR7 complex with EpoR

PDB ID 6mok

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