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6mv2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==2.05A resolution structure of the CS-b5R domains of human Ncb5or (NADP+ form)== | |
| - | + | <StructureSection load='6mv2' size='340' side='right'caption='[[6mv2]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mv2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MV2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-b5_reductase Cytochrome-b5 reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.2.2 1.6.2.2] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mv2 OCA], [http://pdbe.org/6mv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mv2 RCSB], [http://www.ebi.ac.uk/pdbsum/6mv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mv2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NB5R4_HUMAN NB5R4_HUMAN]] NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cytochrome-b5 reductase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Battaile, K P]] | ||
| + | [[Category: Benson, D R]] | ||
| + | [[Category: Cooper, A]] | ||
| + | [[Category: Gao, P]] | ||
| + | [[Category: Lovell, S]] | ||
| + | [[Category: Mehzabeen, N]] | ||
| + | [[Category: Zhu, H]] | ||
| + | [[Category: Electron transfer]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: Flavoprotein]] | ||
| + | [[Category: Heme]] | ||
| + | [[Category: Iron]] | ||
| + | [[Category: Metal-binding]] | ||
| + | [[Category: Ncb5or]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Redox]] | ||
Revision as of 10:45, 17 July 2019
2.05A resolution structure of the CS-b5R domains of human Ncb5or (NADP+ form)
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Categories: Cytochrome-b5 reductase | Large Structures | Battaile, K P | Benson, D R | Cooper, A | Gao, P | Lovell, S | Mehzabeen, N | Zhu, H | Electron transfer | Endoplasmic reticulum | Flavoprotein | Heme | Iron | Metal-binding | Ncb5or | Oxidoreductase | Redox
