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2uwq

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[[Image:2uwq.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwq OCA], [http://www.ebi.ac.uk/pdbsum/2uwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uwq RCSB]</span>
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'''SOLUTION STRUCTURE OF ASPP2 N-TERMINUS'''
'''SOLUTION STRUCTURE OF ASPP2 N-TERMINUS'''
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[[Category: Rutherford, T J.]]
[[Category: Rutherford, T J.]]
[[Category: Tidow, H.]]
[[Category: Tidow, H.]]
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[[Category: ank repeat]]
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[[Category: Ank repeat]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: aspp2]]
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[[Category: Aspp2]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: sh3-binding]]
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[[Category: Sh3-binding]]
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[[Category: sh3-domain]]
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[[Category: Sh3-domain]]
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[[Category: ubiquitin-like]]
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[[Category: Ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:41:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:05:34 2008''
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Revision as of 14:41, 4 May 2008

Image:2uwq.jpg

Template:STRUCTURE 2uwq

SOLUTION STRUCTURE OF ASPP2 N-TERMINUS


Overview

Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.

About this Structure

2UWQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold., Tidow H, Andreeva A, Rutherford TJ, Fersht AR, J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:17594908 Page seeded by OCA on Sun May 4 17:41:06 2008

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