2uxa

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[[Image:2uxa.gif|left|200px]]
[[Image:2uxa.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2uxa |SIZE=350|CAPTION= <scene name='initialview01'>2uxa</scene>, resolution 2.38&Aring;
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The line below this paragraph, containing "STRUCTURE_2uxa", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+1263'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+B+1262'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+C+1263'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+B+1263'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+C+1264'>AC5</scene>, <scene name='pdbsite=AC6:GLU+Binding+Site+For+Residue+A+1264'>AC6</scene>, <scene name='pdbsite=AC7:GLU+Binding+Site+For+Residue+C+1265'>AC7</scene> and <scene name='pdbsite=AC8:GLU+Binding+Site+For+Residue+B+1264'>AC8</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2uxa| PDB=2uxa | SCENE= }}
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|RELATEDENTRY=[[1ftj|1FTJ]], [[1ftk|1FTK]], [[1ftl|1FTL]], [[1ftm|1FTM]], [[1fto|1FTO]], [[1fw0|1FW0]], [[1gr2|1GR2]], [[1lb8|1LB8]], [[1lb9|1LB9]], [[1lbb|1LBB]], [[1lbc|1LBC]], [[1m5b|1M5B]], [[1m5c|1M5C]], [[1m5d|1M5D]], [[1m5e|1M5E]], [[1m5f|1M5F]], [[1mm6|1MM6]], [[1mm7|1MM7]], [[1mqd|1MQD]], [[1mqg|1MQG]], [[1mqh|1MQH]], [[1mqi|1MQI]], [[1mqj|1MQJ]], [[1ms7|1MS7]], [[1mxu|1MXU]], [[1mxv|1MXV]], [[1mxw|1MXW]], [[1mxx|1MXX]], [[1mxy|1MXY]], [[1mxz|1MXZ]], [[1my0|1MY0]], [[1my1|1MY1]], [[1my2|1MY2]], [[1my3|1MY3]], [[1my4|1MY4]], [[1n0t|1N0T]], [[1nnk|1NNK]], [[1nnp|1NNP]], [[1p1n|1P1N]], [[1p1o|1P1O]], [[1p1q|1P1Q]], [[1p1u|1P1U]], [[1p1w|1P1W]], [[1syh|1SYH]], [[1syi|1SYI]], [[1wvj|1WVJ]], [[1xhy|1XHY]], [[2aix|2AIX]], [[2al4|2AL4]], [[2al5|2AL5]], [[2anj|2ANJ]], [[2cmo|2CMO]], [[2i3v|2I3V]], [[2i3w|2I3W]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uxa OCA], [http://www.ebi.ac.uk/pdbsum/2uxa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uxa RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE GLUR2-FLIP LIGAND BINDING DOMAIN, R/G UNEDITED.'''
'''CRYSTAL STRUCTURE OF THE GLUR2-FLIP LIGAND BINDING DOMAIN, R/G UNEDITED.'''
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[[Category: Khatri, L.]]
[[Category: Khatri, L.]]
[[Category: Ziff, E B.]]
[[Category: Ziff, E B.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: ampa]]
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[[Category: Ampa]]
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[[Category: glur2]]
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[[Category: Glur2]]
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[[Category: glutamate receptor]]
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[[Category: Glutamate receptor]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: ionic channel]]
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[[Category: Ionic channel]]
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[[Category: ligand binding domain]]
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[[Category: Ligand binding domain]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: palmitate]]
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[[Category: Palmitate]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: postsynaptic membrane]]
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[[Category: Postsynaptic membrane]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: rna editing]]
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[[Category: Rna editing]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:43:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:05:53 2008''
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Revision as of 14:43, 4 May 2008

Image:2uxa.gif

Template:STRUCTURE 2uxa

CRYSTAL STRUCTURE OF THE GLUR2-FLIP LIGAND BINDING DOMAIN, R/G UNEDITED.


Overview

The subunit composition determines AMPA receptor (AMPA-R) function and trafficking. Mechanisms underlying channel assembly are thus central to the efficacy and plasticity of glutamatergic synapses. We previously showed that RNA editing at the Q/R site of the GluR2 subunit contributes to the assembly of AMPA-R heteromers by attenuating formation of GluR2 homotetramers. Here we report that this function of the Q/R site depends on subunit contacts between adjacent ligand binding domains (LBDs). Changes of LBD interface contacts alter GluR2 assembly properties, forward traffic, and expression at synapses. Interestingly, developmentally regulated RNA editing within the LBD (at the R/G site) produces analogous effects. Our data reveal that editing to glycine reduces the self-assembly competence of this critical subunit and slows GluR2 maturation in the endoplasmic reticulum (ER). Therefore, RNA editing sites, located at strategic subunit interfaces, shape AMPA-R assembly and trafficking in a developmentally regulated manner.

About this Structure

2UXA is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis., Greger IH, Akamine P, Khatri L, Ziff EB, Neuron. 2006 Jul 6;51(1):85-97. PMID:16815334 Page seeded by OCA on Sun May 4 17:43:38 2008

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OCA

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