2uyz

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[[Image:2uyz.gif|left|200px]]
[[Image:2uyz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2uyz |SIZE=350|CAPTION= <scene name='initialview01'>2uyz</scene>, resolution 1.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2uyz", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2uyz| PDB=2uyz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyz OCA], [http://www.ebi.ac.uk/pdbsum/2uyz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uyz RCSB]</span>
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}}
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'''NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1'''
'''NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1'''
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[[Category: Olsen, J V.]]
[[Category: Olsen, J V.]]
[[Category: Sixma, T K.]]
[[Category: Sixma, T K.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: chromosome partition]]
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[[Category: Chromosome partition]]
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[[Category: conjugating enzyme]]
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[[Category: Conjugating enzyme]]
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[[Category: e2]]
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[[Category: E2]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: mitosis]]
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[[Category: Mitosis]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: sumo1]]
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[[Category: Sumo1]]
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[[Category: sumoylation]]
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[[Category: Sumoylation]]
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[[Category: ubc9]]
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[[Category: Ubc9]]
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[[Category: ubiquitin-like modifier]]
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[[Category: Ubiquitin-like modifier]]
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[[Category: ubl conjugation pathway]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:50:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:26 2008''
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Revision as of 14:50, 4 May 2008

Image:2uyz.gif

Template:STRUCTURE 2uyz

NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1


Overview

The ubiquitin-related modifier SUMO regulates a wide range of cellular processes by post-translational modification with one, or a chain of SUMO molecules. Sumoylation is achieved by the sequential action of several enzymes in which the E2, Ubc9, transfers SUMO from the E1 to the target mostly with the help of an E3 enzyme. In this process, Ubc9 not only forms a thioester bond with SUMO, but also interacts with SUMO noncovalently. Here, we show that this noncovalent interaction promotes the formation of short SUMO chains on targets such as Sp100 and HDAC4. We present a crystal structure of the noncovalent Ubc9-SUMO1 complex, showing that SUMO is located far from the E2 active site and resembles the noncovalent interaction site for ubiquitin on UbcH5c and Mms2. Structural comparison suggests a model for poly-sumoylation involving a mechanism analogous to Mms2-Ubc13-mediated ubiquitin chain formation.

About this Structure

2UYZ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation., Knipscheer P, van Dijk WJ, Olsen JV, Mann M, Sixma TK, EMBO J. 2007 Jun 6;26(11):2797-807. Epub 2007 May 10. PMID:17491593 Page seeded by OCA on Sun May 4 17:50:40 2008

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