Calcium/Calmodulin-dependent protein kinase

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CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>
CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>
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== 3D Structures of Calcium/calmodulin dependent protein kinase ==
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[[Calcium/calmodulin dependent protein kinase 3D structures]]
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**[[5hu3]], [[5h9b]], [[5fg8]] - hCaMKII α chain + potassium channel protein EAG<br />
**[[5hu3]], [[5h9b]], [[5fg8]] - hCaMKII α chain + potassium channel protein EAG<br />
**[[2vz6]] - hCaMKII α + indirubin-E804<br />
**[[2vz6]] - hCaMKII α + indirubin-E804<br />
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**[[6of8]] - hCaMKII α chain HUB domain (mutant)<br />
**[[3bhh]] - hCaMKII β <br />
**[[3bhh]] - hCaMKII β <br />
**[[2zv2]] – hCaMKII β +STO-609<br />
**[[2zv2]] – hCaMKII β +STO-609<br />
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**[[6hcs]] - hCaMKII β chain + calmodulin<br />
**[[2v7o]] - hCaMKII γ <br />
**[[2v7o]] - hCaMKII γ <br />
**[[2ux0]] - hCaMKII γ (mutant) <br />
**[[2ux0]] - hCaMKII γ (mutant) <br />

Revision as of 08:56, 18 April 2019

Human CamKII subunit α kinase domain complex with indirubin (PDB code 2vz6)

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3D Structures of Calcium/calmodulin dependent protein kinase

Updated on 18-April-2019

References

  1. ↑ Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654 doi:10.1371/journal.pbio.1000426

See Calcium-dependent protein kinase

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Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky

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