2v1y

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[[Image:2v1y.gif|left|200px]]
[[Image:2v1y.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2v1y |SIZE=350|CAPTION= <scene name='initialview01'>2v1y</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2v1y", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2v1y| PDB=2v1y | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1y OCA], [http://www.ebi.ac.uk/pdbsum/2v1y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v1y RCSB]</span>
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}}
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'''STRUCTURE OF A PHOSPHOINOSITIDE 3-KINASE ALPHA ADAPTOR-BINDING DOMAIN (ABD) IN A COMPLEX WITH THE ISH2 DOMAIN FROM P85 ALPHA'''
'''STRUCTURE OF A PHOSPHOINOSITIDE 3-KINASE ALPHA ADAPTOR-BINDING DOMAIN (ABD) IN A COMPLEX WITH THE ISH2 DOMAIN FROM P85 ALPHA'''
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[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
[[Category: Zvelebil, M.]]
[[Category: Zvelebil, M.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: cancer]]
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[[Category: Cancer]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: host-virus interaction]]
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[[Category: Host-virus interaction]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: oncogenic mutation]]
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[[Category: Oncogenic mutation]]
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[[Category: phosphoinositide]]
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[[Category: Phosphoinositide]]
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[[Category: phosphoinositide 3-kinase]]
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[[Category: Phosphoinositide 3-kinase]]
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[[Category: phospholipid]]
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[[Category: Phospholipid]]
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[[Category: phospholipid signalling]]
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[[Category: Phospholipid signalling]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: sh2 domain]]
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[[Category: Sh2 domain]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: ubl conjugation]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:03:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:36 2008''
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Revision as of 15:03, 4 May 2008

Image:2v1y.gif

Template:STRUCTURE 2v1y

STRUCTURE OF A PHOSPHOINOSITIDE 3-KINASE ALPHA ADAPTOR-BINDING DOMAIN (ABD) IN A COMPLEX WITH THE ISH2 DOMAIN FROM P85 ALPHA


Overview

Many human cancers involve up-regulation of the phosphoinositide 3-kinase PI3Kalpha, with oncogenic mutations identified in both the p110alpha catalytic and the p85alpha regulatory subunits. We used crystallographic and biochemical approaches to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains. A structure of the adaptor-binding domain of p110alpha in a complex with the p85alpha inter-Src homology 2 (inter-SH2) domain shows that oncogenic mutations in the adaptor-binding domain are not at the inter-SH2 interface but in a polar surface patch that is a plausible docking site for other domains in the holo p110/p85 complex. We also examined helical domain mutations and found that the Glu545 to Lys545 (E545K) oncogenic mutant disrupts an inhibitory charge-charge interaction with the p85 N-terminal SH2 domain. These studies extend our understanding of the architecture of PI3Ks and provide insight into how two classes of mutations that cause a gain in function can lead to cancer.

About this Structure

2V1Y is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit., Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL, Science. 2007 Jul 13;317(5835):239-42. PMID:17626883 Page seeded by OCA on Sun May 4 18:03:44 2008

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