2-oxoisovalerate dehydrogenase
From Proteopedia
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== Function == | == Function == | ||
| - | '''2-oxoisovalerate dehydrogenase''' (OIVD) is part of a multienzyme complex metabolizing pyruvate, 2-oxogluterate and branched-chain 2-oxo acids. The active site of OIVD contains the cofactor thiamin diphosphate (TDP) | + | '''2-oxoisovalerate dehydrogenase''' (OIVD) or '''branched-chain α-keto acid decarboxylase''' is part of a multienzyme complex metabolizing pyruvate, 2-oxogluterate and branched-chain 2-oxo acids. The multienzyme complex contains OIVD, lipoamide acyltransferase and lipoamide dehydrogenase. The active site of OIVD contains the cofactor thiamin diphosphate (TDP)<ref>PMID:10426958</ref>. |
| - | <ref>PMID:10426958</ref>. | + | |
== Disease == | == Disease == | ||
Revision as of 08:52, 6 November 2018
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3D structures of 2-oxoisovalerate dehydrogenase
Updated on 06-November-2018
2bp7 - OIVD α+β subunits - Pseudomonas putida
1v1r - hOIVD α+β subunits - human
1u5b, 1x80, 1ols - hOIVD α+β subunits + TDP
1x7x, 1x7w, 1x7y, 1x7z, 2j9f, 1olu, 2bfb, 2bfd, 2bfe, 1v11 - hOIVD α (mutant)+ β subunits + TDP derivative
1olx - hOIVD α+β (mutant) subunits + TDP
1wci - hOIVD α+β subunits + thiamine derivative
2bfe - hOIVD α+β subunits + pyrimidine derivative
2bfc - hOIVD α (mutant)+ β subunits + pyrimidine derivative
1v16 - hOIVD α+β subunits + TDP + benzamidine
1v1m - hOIVD α (mutant)+ β subunits + TDP + benzamidine
2bew, 2beu, 2bev - hOIVD α+β subunits + TDP derivative + peptide
References
- ↑ Aevarsson A, Seger K, Turley S, Sokatch JR, Hol WG. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. Nat Struct Biol. 1999 Aug;6(8):785-92. PMID:10426958 doi:10.1038/11563
