This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sialidase
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | ''' | + | '''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. '''Trans-sialidase''' is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>, <ref>PMID:8405811</ref>. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| + | |||
| + | ''Trypanosoma cruzi'' trans-sialidase is a drug target agains Chagas Disease<ref>PMID:24144418</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| Line 89: | Line 91: | ||
**[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br /> | **[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br /> | ||
**[[3opz]] - TcSal (mutant) + antibody<br /> | **[[3opz]] - TcSal (mutant) + antibody<br /> | ||
| - | **[[1sli]], [[2sli]], [[3sli]], [[4sli]] - | + | **[[1sll]] – lSal L - leech<br /> |
| + | **[[1sli]], [[2sli]], [[3sli]], [[4sli]] - lSal + neuraminic acid derivative <br /> | ||
**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br /> | **[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br /> | ||
**[[4x49]] - RgSal + tamiflu<br /> | **[[4x49]] - RgSal + tamiflu<br /> | ||
Revision as of 11:30, 6 November 2018
| |||||||||||
3D structures of salidase
Updated on 06-November-2018
References
- ↑ Monti E, Preti A, Venerando B, Borsani G. Recent development in mammalian sialidase molecular biology. Neurochem Res. 2002 Aug;27(7-8):649-63. PMID:12374200
- ↑ Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC. A sialidase mutant displaying trans-sialidase activity. J Mol Biol. 2005 Jan 28;345(4):923-34. PMID:15588836 doi:10.1016/j.jmb.2004.09.031
- ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
- ↑ Miller BR 3rd, Roitberg AE. Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis). Future Med Chem. 2013 Oct;5(15):1889-900. doi: 10.4155/fmc.13.129. PMID:24144418 doi:http://dx.doi.org/10.4155/fmc.13.129
