Cysteine desulfurase

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*<scene name='80/800705/Cv/4'>All interactions of PLP</scene>.
*<scene name='80/800705/Cv/4'>All interactions of PLP</scene>.
<scene name='80/800705/Cv/5'>Cys361 is the nucleophilic catalytic residue</scene>. The reaction product <scene name='80/800705/Cv/6'>alanine is bound near the Cys361-persulfide</scene><ref>PMID:27382962</ref>.
<scene name='80/800705/Cv/5'>Cys361 is the nucleophilic catalytic residue</scene>. The reaction product <scene name='80/800705/Cv/6'>alanine is bound near the Cys361-persulfide</scene><ref>PMID:27382962</ref>.
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</StructureSection>
 
==3D structures of cysteine desulfurase==
==3D structures of cysteine desulfurase==
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[[Cysteine desulfurase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Cysteine desulfurase complexes not containing cysteine
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**[[5xt5]] - BsSUFS + SufU + PLP - ''Bacillus subtilis''<br />
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**[[1t3i]] - SUFS + PLP - ''Synechocystis''<br />
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**[[4q76]] - AtSUFS 2 (mutant) + PLP derivative <br />
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**[[4r5f]] - SUFS 2 (mutant) + PLP derivative - ''Archaeoglobus fulgidus''<br />
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**[[4w91]] - SUFS + PLP derivative - ''Brucella suis''<br />
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**[[5b7s]] - ToSUFS + PLP derivative - ''Thermococcus onnurineus''<br />
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**[[5ft4]], [[4lw2]], [[4lw4]], [[1p3w]], [[3lvm]] - EcSUFS IscS + PLP - ''Escherichia coli''<br />
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**[[3lvj]], [[3lvk]] - EcSUFS IscS + tusA + PLP <br />
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**[[3lvl]] - EcSUFS IscS + NifU-like protein + PLP <br />
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**[[6c9e]] - SUFS + PLP derivative - ''Legionella pneumophila''<br />
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**[[5wt2]] - HpSUFS IscS + PLP<br />
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**[[5wt5]] - HpSUFS IscS (mutant) + PLP derivative + mercapto butyric acid <br />
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**[[5vpr]] - SUFS + PLP - ''Elizabethkingia anophelis'' <br />
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**[[5wgb]], [[5wkp]], [[5usr]] - hSUFS + LYR motif-containing protein + acyl carrier protein + PLP - human <br />
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**[[5wlw]] - hSUFS + LYR motif-containing protein + acyl carrier protein + IscU + PLP <br />
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**[[5kz5]] - hSUFS + frataxin + IscU <br />
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**[[4isy]] - SUFS IscS + PLP derivative - ''Mycobacterium tuberculosis''<br />
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*Cysteine desulfurase complexes containing cysteine
 
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**[[5j8q]] - BsSUFS + mercaptocysteine + PLP + alanine <br />
 
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**[[5xt6]] - BsSUFS + SufU + mercaptocysteine + PLP derivative <br />
 
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**[[4q75]] - AtSUFS 2 + mercaptocysteine + PLP derivative - ''Arabidopsis thaliana''<br />
 
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**[[5b7u]] - ToSUFS + mercaptocysteine + PLP derivative + cysteine<br />
 
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**[[5b87]], [[5b89]] - ToSUFS + mercaptocysteine + PLP + alanine<br />
 
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**[[5ft5]] - EcSUFS CsdA + mercaptocysteine + PLP <br />
 
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**[[5ft6]] - EcSUFS CsdA + cysteine sulfonic acid + PLP <br />
 
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**[[5ft8]] - EcSUFS CsdA + sulfur acceptor protein + mercaptocysteine + PLP <br />
 
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**[[5db5]] - EcSUFS + mercaptocysteine + PLP + cysteine<br />
 
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**[[5wt4]] - HpSUFS IscS (mutant) + PLP derivative + cysteine derivative - ''Helicobacter pylori''<br />
 
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**[[5wt6]] - HpSUFS IscS + mercaptocysteine + PLP derivative <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:31, 23 May 2019

Bacterial cysteine desulfurase complex with PLP, mercaptocysteine and alanine (PDB code 5j8q)

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References

  1. ↑ Mihara H, Esaki N. Bacterial cysteine desulfurases: their function and mechanisms. Appl Microbiol Biotechnol. 2002 Oct;60(1-2):12-23. doi:, 10.1007/s00253-002-1107-4. Epub 2002 Sep 4. PMID:12382038 doi:http://dx.doi.org/10.1007/s00253-002-1107-4
  2. ↑ Blauenburg B, Mielcarek A, Altegoer F, Fage CD, Linne U, Bange G, Marahiel MA. Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU. PLoS One. 2016 Jul 6;11(7):e0158749. doi: 10.1371/journal.pone.0158749., eCollection 2016. PMID:27382962 doi:http://dx.doi.org/10.1371/journal.pone.0158749

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Alexander Berchansky, Michal Harel

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