6mvl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of VISTA bound to a pH-selective antibody Fab fragment== | |
| - | + | <StructureSection load='6mvl' size='340' side='right'caption='[[6mvl]], [[Resolution|resolution]] 1.61Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mvl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MVL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mvl OCA], [http://pdbe.org/6mvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mvl RCSB], [http://www.ebi.ac.uk/pdbsum/6mvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mvl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VISTA_HUMAN VISTA_HUMAN]] Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).[UniProtKB:Q9D659]<ref>PMID:20666777</ref> <ref>PMID:24691993</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Critton, D A]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Checkpoint]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunoglobulin]] | ||
Revision as of 06:53, 23 October 2019
Crystal structure of VISTA bound to a pH-selective antibody Fab fragment
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