2v71

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2v71.gif|left|200px]]
[[Image:2v71.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2v71 |SIZE=350|CAPTION= <scene name='initialview01'>2v71</scene>, resolution 2.24&Aring;
+
The line below this paragraph, containing "STRUCTURE_2v71", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2v71| PDB=2v71 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v71 OCA], [http://www.ebi.ac.uk/pdbsum/2v71 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v71 RCSB]</span>
+
-
}}
+
'''COILED-COIL REGION OF NUDEL'''
'''COILED-COIL REGION OF NUDEL'''
Line 29: Line 26:
[[Category: Derewenda, Z S.]]
[[Category: Derewenda, Z S.]]
[[Category: Kim, M H.]]
[[Category: Kim, M H.]]
-
[[Category: alternative splicing]]
+
[[Category: Alternative splicing]]
-
[[Category: coiled coil]]
+
[[Category: Coiled coil]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: cytoskeleton]]
+
[[Category: Cytoskeleton]]
-
[[Category: developmental protein]]
+
[[Category: Developmental protein]]
-
[[Category: differentiation]]
+
[[Category: Differentiation]]
-
[[Category: lis1 binding]]
+
[[Category: Lis1 binding]]
-
[[Category: microtubule]]
+
[[Category: Microtubule]]
-
[[Category: microtubule associated migration]]
+
[[Category: Microtubule associated migration]]
-
[[Category: neurogenesis]]
+
[[Category: Neurogenesis]]
-
[[Category: nuclear protein]]
+
[[Category: Nuclear protein]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: transport]]
+
[[Category: Transport]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:18:03 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:00 2008''
+

Revision as of 15:18, 4 May 2008

Image:2v71.gif

Template:STRUCTURE 2v71

COILED-COIL REGION OF NUDEL


Overview

Ndel1 and Nde1 are homologous and evolutionarily conserved proteins, with critical roles in cell division, neuronal migration, and other physiological phenomena. These functions are dependent on their interactions with the retrograde microtubule motor dynein and with its regulator Lis1--a product of the causal gene for isolated lissencephaly sequence (ILS) and Miller-Dieker lissencephaly. The molecular basis of the interactions of Ndel1 and Nde1 with Lis1 is not known. Here, we present a crystallographic study of two fragments of the coiled-coil domain of Ndel1, one of which reveals contiguous high-quality electron density for residues 10-166, the longest such structure reported by X-ray diffraction at high resolution. Together with complementary solution studies, our structures reveal how the Ndel1 coiled coil forms a stable parallel homodimer and suggest mechanisms by which the Lis1-interacting domain can be regulated to maintain a conformation in which two supercoiled alpha helices cooperatively bind to a Lis1 homodimer.

About this Structure

2V71 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly., Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS, Structure. 2007 Nov;15(11):1467-81. PMID:17997972 Page seeded by OCA on Sun May 4 18:18:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v71"
Personal tools