2v7g

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[[Image:2v7g.jpg|left|200px]]
[[Image:2v7g.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v7g |SIZE=350|CAPTION= <scene name='initialview01'>2v7g</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2v7g", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nad+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Nad+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Nad+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Nad+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:Act+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Act+Binding+Site+For+Chain+B'>AC6</scene>, <scene name='pdbsite=AC7:Act+Binding+Site+For+Chain+B'>AC7</scene>, <scene name='pdbsite=AC8:Act+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:Act+Binding+Site+For+Chain+B'>AC9</scene>, <scene name='pdbsite=BC1:Act+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:Act+Binding+Site+For+Chain+C'>BC2</scene>, <scene name='pdbsite=BC3:Gol+Binding+Site+For+Chain+B'>BC3</scene>, <scene name='pdbsite=BC4:Gol+Binding+Site+For+Chain+D'>BC4</scene>, <scene name='pdbsite=BC5:Gol+Binding+Site+For+Chain+B'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Chain+D'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Chain+A'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Chain+D'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Chain+B'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Chain+A'>CC1</scene> and <scene name='pdbsite=CC2:Gol+Binding+Site+For+Chain+D'>CC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Urocanate_hydratase Urocanate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.49 4.2.1.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2v7g| PDB=2v7g | SCENE= }}
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|RELATEDENTRY=[[1uwk|1UWK]], [[1uwl|1UWL]], [[1w1u|1W1U]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7g OCA], [http://www.ebi.ac.uk/pdbsum/2v7g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v7g RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF AN ENGINEERED UROCANASE TETRAMER'''
'''CRYSTAL STRUCTURE OF AN ENGINEERED UROCANASE TETRAMER'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Treiber, N.]]
[[Category: Treiber, N.]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: histidine degradation]]
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[[Category: Histidine degradation]]
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[[Category: histidine metabolism]]
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[[Category: Histidine metabolism]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: nad]]
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[[Category: Nad]]
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[[Category: protein engineering]]
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[[Category: Protein engineering]]
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[[Category: urocanate hydratase]]
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[[Category: Urocanate hydratase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:19:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:13 2008''
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Revision as of 15:19, 4 May 2008

Image:2v7g.jpg

Template:STRUCTURE 2v7g

CRYSTAL STRUCTURE OF AN ENGINEERED UROCANASE TETRAMER


Overview

The analysis of natural contact interfaces between protein subunits and between proteins has disclosed some general rules governing their association. We have applied these rules to produce a number of novel assemblies, demonstrating that a given protein can be engineered to form contacts at various points of its surface. Symmetry plays an important role because it defines the multiplicity of a designed contact and therefore the number of required mutations. Some of the proteins needed only a single side-chain alteration in order to associate to a higher-order complex. The mobility of the buried side chains has to be taken into account. Four assemblies have been structurally elucidated. Comparisons between the designed contacts and the results will provide useful guidelines for the development of future architectures.

About this Structure

2V7G is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Designed protein-protein association., Grueninger D, Treiber N, Ziegler MO, Koetter JW, Schulze MS, Schulz GE, Science. 2008 Jan 11;319(5860):206-9. PMID:18187656 Page seeded by OCA on Sun May 4 18:19:28 2008

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