4cqs

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==H5 (VN1194) Asn186Lys Mutant Haemagglutinin in Complex with Avian Receptor Analogue 3'SLN==
==H5 (VN1194) Asn186Lys Mutant Haemagglutinin in Complex with Avian Receptor Analogue 3'SLN==
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<StructureSection load='4cqs' size='340' side='right' caption='[[4cqs]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='4cqs' size='340' side='right'caption='[[4cqs]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Vietnam/1194/2004(H5N1)) Influenza A virus (A/Vietnam/1194/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqx|4cqx]], [[4cqy|4cqy]], [[4cqz|4cqz]], [[4cr0|4cr0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqs OCA], [https://pdbe.org/4cqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cqs RCSB], [https://www.ebi.ac.uk/pdbsum/4cqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqs ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644788 Influenza A virus (A/Viet Nam/1194/2004(H5N1))])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqs OCA], [http://pdbe.org/4cqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cqs RCSB], [http://www.ebi.ac.uk/pdbsum/4cqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqs ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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[[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Collins, P J]]
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[[Category: Large Structures]]
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[[Category: Coombs, P J]]
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[[Category: Collins PJ]]
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[[Category: Gamblin, S J]]
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[[Category: Coombs PJ]]
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[[Category: Lin, Y P]]
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[[Category: Gamblin SJ]]
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[[Category: Liu, J]]
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[[Category: Lin YP]]
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[[Category: Martin, S R]]
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[[Category: Liu J]]
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[[Category: McCauley, J W]]
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[[Category: Martin SR]]
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[[Category: Skehel, J J]]
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[[Category: McCauley JW]]
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[[Category: Vachieri, S G]]
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[[Category: Skehel JJ]]
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[[Category: Walker, P A]]
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[[Category: Vachieri SG]]
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[[Category: Xiao, H]]
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[[Category: Walker PA]]
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[[Category: Xiong, X]]
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[[Category: Xiao H]]
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[[Category: 3'sln]]
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[[Category: Xiong X]]
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[[Category: 6'sln]]
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[[Category: Avian flu]]
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[[Category: Glycoprotein]]
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[[Category: Lsta]]
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[[Category: Sialic acid]]
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[[Category: Sialyllactosamine]]
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[[Category: Viral protein]]
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[[Category: Virus receptor]]
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Revision as of 07:28, 14 September 2022

H5 (VN1194) Asn186Lys Mutant Haemagglutinin in Complex with Avian Receptor Analogue 3'SLN

PDB ID 4cqs

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