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2v8n

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[[Image:2v8n.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_2v8n| PDB=2v8n | SCENE= }}
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|RELATEDENTRY=[[1pv6|1PV6]], [[1pv7|1PV7]], [[2cfp|2CFP]], [[1m2u|1M2U]], [[2cfq|2CFQ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8n OCA], [http://www.ebi.ac.uk/pdbsum/2v8n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v8n RCSB]</span>
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'''WILD-TYPE STRUCTURE OF LACTOSE PERMEASE'''
'''WILD-TYPE STRUCTURE OF LACTOSE PERMEASE'''
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[[Category: Mirza, O.]]
[[Category: Mirza, O.]]
[[Category: Verner, G.]]
[[Category: Verner, G.]]
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[[Category: formylation]]
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[[Category: Formylation]]
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[[Category: inner membrane]]
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[[Category: Inner membrane]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: sugar transport]]
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[[Category: Sugar transport]]
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[[Category: symport]]
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[[Category: Symport]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:36 2008''
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Revision as of 15:22, 4 May 2008

Image:2v8n.jpg

Template:STRUCTURE 2v8n

WILD-TYPE STRUCTURE OF LACTOSE PERMEASE


Overview

Here we describe an x-ray structure of wild-type lactose permease (LacY) from Escherichia coli determined by manipulating phospholipid content during crystallization. The structure exhibits the same global fold as the previous x-ray structures of a mutant that binds sugar but cannot catalyze translocation across the membrane. LacY is organized into two six-helix bundles with twofold pseudosymmetry separated by a large interior hydrophilic cavity open only to the cytoplasmic side and containing the side chains important for sugar and H(+) binding. To initiate transport, binding of sugar and/or an H(+) electrochemical gradient increases the probability of opening on the periplasmic side. Because the inward-facing conformation represents the lowest free-energy state, the rate-limiting step for transport may be the conformational change leading to the outward-facing conformation.

About this Structure

2V8N is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural determination of wild-type lactose permease., Guan L, Mirza O, Verner G, Iwata S, Kaback HR, Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15294-8. Epub 2007 Sep 19. PMID:17881559 Page seeded by OCA on Sun May 4 18:22:33 2008

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