2vbs

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[[Image:2vbs.gif|left|200px]]
[[Image:2vbs.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2vbs |SIZE=350|CAPTION= <scene name='initialview01'>2vbs</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2vbs", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Cl+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Cl+Binding+Site+For+Chain+A'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2vbs| PDB=2vbs | SCENE= }}
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|RELATEDENTRY=[[2p3m|2P3M]], [[2vbt|2VBT]], [[2vbv|2VBV]], [[2vbu|2VBU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbs OCA], [http://www.ebi.ac.uk/pdbsum/2vbs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vbs RCSB]</span>
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}}
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'''RIBOFLAVIN KINASE MJ0056 FROM METHANOCALDOCOCCUS JANNASCHII IN COMPLEX WITH PO4'''
'''RIBOFLAVIN KINASE MJ0056 FROM METHANOCALDOCOCCUS JANNASCHII IN COMPLEX WITH PO4'''
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[[Category: Martin, J.]]
[[Category: Martin, J.]]
[[Category: Zeth, K.]]
[[Category: Zeth, K.]]
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[[Category: cradle-loop barrel]]
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[[Category: Cradle-loop barrel]]
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[[Category: ctp-dependent kinase]]
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[[Category: Ctp-dependent kinase]]
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[[Category: fmn]]
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[[Category: Fmn]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:33:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:10:42 2008''
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Revision as of 15:33, 4 May 2008

Image:2vbs.gif

Template:STRUCTURE 2vbs

RIBOFLAVIN KINASE MJ0056 FROM METHANOCALDOCOCCUS JANNASCHII IN COMPLEX WITH PO4


Overview

Proteins of the cradle-loop barrel metafold are formed by duplication of a conserved betaalphabeta-element, suggesting a common evolutionary origin from an ancestral group of nucleic acid-binding proteins. The basal fold within this metafold, the RIFT barrel, is also found in a wide range of enzymes, whose homologous relationship with the nucleic acid-binding group is unclear. We have characterized a protein family that is intermediate in sequence and structure between the basal group of cradle-loop barrels and one family of RIFT-barrel enzymes, the riboflavin kinases. We report the structure, substrate-binding mode, and catalytic activity for one of these proteins, Methanocaldococcus jannaschii Mj0056, which is an archaeal riboflavin kinase. Mj0056 is unusual in utilizing CTP rather than ATP as the donor nucleotide, and sequence conservation in the relevant residues suggests that this is a general feature of archaeal riboflavin kinases.

About this Structure

2VBS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels., Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, Coles M, Structure. 2007 Dec;15(12):1577-90. PMID:18073108 Page seeded by OCA on Sun May 4 18:33:31 2008

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