3cfo

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==Triple Mutant APO structure==
==Triple Mutant APO structure==
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<StructureSection load='3cfo' size='340' side='right' caption='[[3cfo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3cfo' size='340' side='right'caption='[[3cfo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cfo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_rb69 Bacteriophage rb69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CFO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_rb69 Bacteriophage rb69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ih7|1ih7]], [[1ig9|1ig9]], [[3cfp|3cfp]], [[3cfr|3cfr]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ih7|1ih7]], [[1ig9|1ig9]], [[3cfp|3cfp]], [[3cfr|3cfr]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">43 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12353 Bacteriophage RB69])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">43 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12353 Bacteriophage RB69])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfo OCA], [http://pdbe.org/3cfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cfo RCSB], [http://www.ebi.ac.uk/pdbsum/3cfo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfo OCA], [https://pdbe.org/3cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfo RCSB], [https://www.ebi.ac.uk/pdbsum/3cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69]] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
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[[https://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69]] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Bacteriophage rb69]]
[[Category: Bacteriophage rb69]]
[[Category: DNA-directed DNA polymerase]]
[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
[[Category: Klimenko, D]]
[[Category: Klimenko, D]]
[[Category: Konigsberg, W H]]
[[Category: Konigsberg, W H]]

Revision as of 19:09, 20 October 2021

Triple Mutant APO structure

PDB ID 3cfo

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