2veb

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[[Image:2veb.jpg|left|200px]]
[[Image:2veb.jpg|left|200px]]
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{{Structure
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|PDB= 2veb |SIZE=350|CAPTION= <scene name='initialview01'>2veb</scene>, resolution 1.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2veb", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Chain+A'>AC4</scene> and <scene name='pdbsite=AC5:Oxy+Binding+Site+For+Chain+A'>AC5</scene>
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_2veb| PDB=2veb | SCENE= }}
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|RELATEDENTRY=[[2vee|2VEE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2veb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veb OCA], [http://www.ebi.ac.uk/pdbsum/2veb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2veb RCSB]</span>
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}}
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'''HIGH RESOLUTION STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A'''
'''HIGH RESOLUTION STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A'''
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[[Category: Saito, J A.]]
[[Category: Saito, J A.]]
[[Category: Thijs, L.]]
[[Category: Thijs, L.]]
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[[Category: archaea protein]]
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[[Category: Archaea protein]]
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[[Category: hemoprotein structure]]
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[[Category: Hemoprotein structure]]
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[[Category: methanogenesis]]
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[[Category: Methanogenesis]]
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[[Category: protein matrix tunnel]]
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[[Category: Protein matrix tunnel]]
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[[Category: protoglobin]]
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[[Category: Protoglobin]]
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[[Category: transport protein]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:39:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:13 2008''
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Revision as of 15:39, 4 May 2008

Image:2veb.jpg

Template:STRUCTURE 2veb

HIGH RESOLUTION STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A


Overview

The structural adaptability of the globin fold has been highlighted by the recent discovery of the 2-on-2 haemoglobins, of neuroglobin and cytoglobin. Protoglobin from Methanosarcina acetivorans C2A-a strictly anaerobic methanogenic Archaea-is, to the best of our knowledge, the latest entry adding new variability and functional complexity to the haemoglobin (Hb) superfamily. Here, we report the 1.3 A crystal structure of oxygenated M. acetivorans protoglobin, together with the first insight into its ligand-binding properties. We show that, contrary to all known globins, protoglobin-specific loops and an amino-terminal extension completely bury the haem within the protein matrix. Access of O(2), CO and NO to the haem is granted by the protoglobin-specific apolar tunnels reaching the haem distal site from locations at the B/G and B/E helix interfaces. Functionally, M. acetivorans dimeric protoglobin shows a selectivity ratio for O(2)/CO binding to the haem that favours O(2) ligation and anticooperativity in ligand binding. Both properties are exceptional within the Hb superfamily.

About this Structure

2VEB is a Single protein structure of sequence from Methanosarcina acetivorans. Full crystallographic information is available from OCA.

Reference

Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity., Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M, EMBO Rep. 2008 Feb;9(2):157-63. Epub 2008 Jan 11. PMID:18188182 Page seeded by OCA on Sun May 4 18:39:23 2008

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