Pseudouridine synthase
From Proteopedia
(Difference between revisions)
(better specify there are two types of complexes among the pseudouridine synthases) |
m (fix link) |
||
| Line 3: | Line 3: | ||
[[Pseudouridine]] is an abundant modified nucleotide found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the base of uridine. There are two major types of enzymes that catalyze this reaction: | [[Pseudouridine]] is an abundant modified nucleotide found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the base of uridine. There are two major types of enzymes that catalyze this reaction: | ||
| - | * [[RNA-guided Pseudoridine synthase] -- | + | * [[RNA-guided Pseudoridine synthase]] -- Complexes of proteins and small RNAs have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to specify the site of modification through base-pairing with the target RNA molecule. |
* [[Guide-independent Pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through stand-alone enzymes to catalyze formation. | * [[Guide-independent Pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through stand-alone enzymes to catalyze formation. | ||
Revision as of 17:07, 13 November 2018
| |||||||||||
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Angel Herraez, Alexander Berchansky, Jaime Prilusky, Wayne Decatur
