6akr

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'''Unreleased structure'''
 
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The entry 6akr is ON HOLD until Paper Publication
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==Crystal structure of the PDE4D catalytic domain in complex with osthole==
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<StructureSection load='6akr' size='340' side='right'caption='[[6akr]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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Authors: Wang, S., Huo, Y.W., Xie, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6akr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AKR FirstGlance]. <br>
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Description: Crystal structure of the PDE4D catalytic domain in complex with osthole
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A0O:7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one'>A0O</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6akr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6akr OCA], [http://pdbe.org/6akr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6akr RCSB], [http://www.ebi.ac.uk/pdbsum/6akr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6akr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
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[[Category: Large Structures]]
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[[Category: Huo, Y W]]
[[Category: Wang, S]]
[[Category: Wang, S]]
[[Category: Xie, Y]]
[[Category: Xie, Y]]
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[[Category: Huo, Y.W]]
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[[Category: Hydrolase]]
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[[Category: Phosphodiesterase 4d]]

Revision as of 04:06, 13 February 2020

Crystal structure of the PDE4D catalytic domain in complex with osthole

PDB ID 6akr

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