6i2t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer== | |
| - | + | <StructureSection load='6i2t' size='340' side='right' caption='[[6i2t]], [[Resolution|resolution]] 5.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6i2t]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I2T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i2t OCA], [http://pdbe.org/6i2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i2t RCSB], [http://www.ebi.ac.uk/pdbsum/6i2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i2t ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cholinesterase]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Bezouwen, L S.van]] | ||
| + | [[Category: Leung, M R]] | ||
[[Category: Lockridge, O]] | [[Category: Lockridge, O]] | ||
| + | [[Category: Schopfer, L M]] | ||
| + | [[Category: Silman, I]] | ||
| + | [[Category: Sussman, J L]] | ||
[[Category: Zeev-Ben-Mordehai, T]] | [[Category: Zeev-Ben-Mordehai, T]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Tetramer]] |
| - | + | ||
Revision as of 08:31, 19 December 2018
CryoEM reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer
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