6i33
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Crystal structure of human glycine decarboxylase (P-protein)== |
| - | + | <StructureSection load='6i33' size='340' side='right'caption='[[6i33]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6i33]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I33 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_dehydrogenase_(decarboxylating) Glycine dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.4.2 1.4.4.2] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i33 OCA], [http://pdbe.org/6i33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i33 RCSB], [http://www.ebi.ac.uk/pdbsum/6i33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i33 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/GCSP_HUMAN GCSP_HUMAN]] Atypical glycine encephalopathy;Infantile glycine encephalopathy;Neonatal glycine encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GCSP_HUMAN GCSP_HUMAN]] The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).<ref>PMID:1993704</ref> <ref>PMID:1996985</ref> <ref>PMID:28244183</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kapp, U]] | ||
| + | [[Category: Laer, B Van]] | ||
| + | [[Category: Leonard, G]] | ||
| + | [[Category: Mueller-Dieckmann, C]] | ||
| + | [[Category: Glycine cleavage system p-protein]] | ||
| + | [[Category: Glycine decarboxylase]] | ||
| + | [[Category: Mitochondrial]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 15:18, 20 November 2019
Crystal structure of human glycine decarboxylase (P-protein)
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