2vg5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2vg5.jpg|left|200px]]
[[Image:2vg5.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2vg5 |SIZE=350|CAPTION= <scene name='initialview01'>2vg5</scene>, resolution 2.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_2vg5", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Nnc+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=NNC:O-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]+(4-CHLOROPHENYL)THIOCARBAMATE'>NNC</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2vg5| PDB=2vg5 | SCENE= }}
-
|RELATEDENTRY=[[1ajv|1AJV]], [[1hps|1HPS]], [[1d4j|1D4J]], [[1r0a|1R0A]], [[1hpz|1HPZ]], [[1hqe|1HQE]], [[1qe1|1QE1]], [[1ajx|1AJX]], [[1tvr|1TVR]], [[1ebk|1EBK]], [[1s6p|1S6P]], [[1bqm|1BQM]], [[1ikv|1IKV]], [[1w5y|1W5Y]], [[1hos|1HOS]], [[1s6q|1S6Q]], [[1ikw|1IKW]], [[3hvt|3HVT]], [[1ec1|1EC1]], [[1ec0|1EC0]], [[1t05|1T05]], [[1rvq|1RVQ]], [[1d4i|1D4I]], [[1meu|1MEU]], [[2be2|2BE2]], [[1s9g|1S9G]], [[1hnv|1HNV]], [[1rvr|1RVR]], [[1ikx|1IKX]], [[1w5w|1W5W]], [[1iky|1IKY]], [[1qmc|1QMC]], [[1n6q|1N6Q]], [[1rvn|1RVN]], [[1d4h|1D4H]], [[1hbv|1HBV]], [[1rtd|1RTD]], [[1htf|1HTF]], [[1ec2|1EC2]], [[1w5v|1W5V]], [[2hmi|2HMI]], [[2uy0|2UY0]], [[1sv5|1SV5]], [[1hmv|1HMV]], [[1s9e|1S9E]], [[1n5y|1N5Y]], [[1dlo|1DLO]], [[1heg|1HEG]], [[1rvp|1RVP]], [[1rvl|1RVL]], [[1dw6|1DW6]], [[1eet|1EET]], [[2b6a|2B6A]], [[1w5x|1W5X]], [[1hvu|1HVU]], [[1htg|1HTG]], [[1ebw|1EBW]], [[2ban|2BAN]], [[1rdh|1RDH]], [[1eby|1EBY]], [[1j5o|1J5O]], [[1hvp|1HVP]], [[1rvo|1RVO]], [[1mes|1MES]], [[1ec3|1EC3]], [[1hih|1HIH]], [[1hef|1HEF]], [[1hni|1HNI]], [[1tv6|1TV6]], [[2b5j|2B5J]], [[1ebz|1EBZ]], [[1hys|1HYS]], [[1met|1MET]], [[1t03|1T03]], [[1axa|1AXA]], [[1mer|1MER]], [[3tlh|3TLH]], [[2uxz|2UXZ]], [[1sbg|1SBG]], [[1hvk|1HVK]], [[1bqn|1BQN]], [[1suq|1SUQ]], [[1uwb|1UWB]], [[1rvm|1RVM]], [[1hte|1HTE]], [[1hrh|1HRH]], [[1hqu|1HQU]], [[2vg6|2VG6]], [[2vg7|2VG7]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vg5 OCA], [http://www.ebi.ac.uk/pdbsum/2vg5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vg5 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURES OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THIOCARBAMATE NON-NUCLEOSIDE INHIBITORS'''
'''CRYSTAL STRUCTURES OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THIOCARBAMATE NON-NUCLEOSIDE INHIBITORS'''
Line 31: Line 28:
[[Category: Spallarossa, A.]]
[[Category: Spallarossa, A.]]
[[Category: Unge, T.]]
[[Category: Unge, T.]]
-
[[Category: aid]]
+
[[Category: Aid]]
-
[[Category: aspartyl protease]]
+
[[Category: Aspartyl protease]]
-
[[Category: capsid maturation]]
+
[[Category: Capsid maturation]]
-
[[Category: core protein]]
+
[[Category: Core protein]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: dna integration]]
+
[[Category: Dna integration]]
-
[[Category: dna recombination]]
+
[[Category: Dna recombination]]
-
[[Category: dna-directed dna polymerase]]
+
[[Category: Dna-directed dna polymerase]]
-
[[Category: endonuclease]]
+
[[Category: Endonuclease]]
-
[[Category: hiv-1]]
+
[[Category: Hiv-1]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: lipoprotein]]
+
[[Category: Lipoprotein]]
-
[[Category: magnesium]]
+
[[Category: Magnesium]]
-
[[Category: membrane]]
+
[[Category: Membrane]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: multifunctional enzyme]]
+
[[Category: Multifunctional enzyme]]
-
[[Category: myristate]]
+
[[Category: Myristate]]
-
[[Category: non-nucleoside reverse transcriptase inhibitor]]
+
[[Category: Non-nucleoside reverse transcriptase inhibitor]]
-
[[Category: nuclease]]
+
[[Category: Nuclease]]
-
[[Category: nucleotidyltransferase]]
+
[[Category: Nucleotidyltransferase]]
-
[[Category: nucleus]]
+
[[Category: Nucleus]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
[[Category: reverse transcriptase]]
+
[[Category: Reverse transcriptase]]
-
[[Category: rna-binding]]
+
[[Category: Rna-binding]]
-
[[Category: rna-directed dna polymerase]]
+
[[Category: Rna-directed dna polymerase]]
-
[[Category: thiocarbamate]]
+
[[Category: Thiocarbamate]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
[[Category: viral nucleoprotein]]
+
[[Category: Viral nucleoprotein]]
-
[[Category: virion]]
+
[[Category: Virion]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
[[Category: zinc-finger]]
+
[[Category: Zinc-finger]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:44:13 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:51 2008''
+

Revision as of 15:44, 4 May 2008

Template:STRUCTURE 2vg5

CRYSTAL STRUCTURES OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THIOCARBAMATE NON-NUCLEOSIDE INHIBITORS


Overview

O-Phthalimidoethyl-N-arylthiocarbamates (TCs) have been recently identified as a new class of potent HIV-1 reverse transcriptase (RT) non-nucleoside inhibitors (NNRTIs), by means of computer-aided drug design techniques [Ranise A. Spallarossa, S. Cesarini, F. Bondavalli, S. Schenone, O. Bruno, G. Menozzi, P. Fossa, L. Mosti, M. La Colla, et al., Structure-based design, parallel synthesis, structure-activity relationship, and molecular modeling studies of thiocarbamates, new potent non-nucleoside HIV-1 reverse transcriptase inhibitor isosteres of phenethylthiazolylthiourea derivatives, J. Med. Chem. 48 (2005) 3858-3873]. To elucidate the atomic details of RT/TC interaction and validate an earlier TC docking model, the structures of three RT/TC complexes were determined at 2.8-3.0A resolution by X-ray crystallography. The conformations adopted by the enzyme-bound TCs were analyzed and compared with those of bioisosterically related NNRTIs.

About this Structure

2VG5 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors., Spallarossa A, Cesarini S, Ranise A, Ponassi M, Unge T, Bolognesi M, Biochem Biophys Res Commun. 2008 Jan 25;365(4):764-70. Epub 2007 Nov 21. PMID:18035053 Page seeded by OCA on Sun May 4 18:44:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools