2vhf

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[[Image:2vhf.jpg|left|200px]]
[[Image:2vhf.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2vhf |SIZE=350|CAPTION= <scene name='initialview01'>2vhf</scene>, resolution 2.800&Aring;
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The line below this paragraph, containing "STRUCTURE_2vhf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+B'>AC3</scene> and <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2vhf| PDB=2vhf | SCENE= }}
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|RELATEDENTRY=[[1ixd|1IXD]], [[1whl|1WHL]], [[1whm|1WHM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vhf OCA], [http://www.ebi.ac.uk/pdbsum/2vhf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vhf RCSB]</span>
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}}
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'''STRUCTURE OF THE CYLD USP DOMAIN'''
'''STRUCTURE OF THE CYLD USP DOMAIN'''
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[[Category: Scheel, H.]]
[[Category: Scheel, H.]]
[[Category: Swift, S.]]
[[Category: Swift, S.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: anti-oncogene]]
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[[Category: Anti-oncogene]]
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[[Category: b-box]]
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[[Category: B-box]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell signalling]]
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[[Category: Cell signalling]]
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[[Category: cross-brace]]
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[[Category: Cross-brace]]
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[[Category: cytokine signalling]]
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[[Category: Cytokine signalling]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: deubiquitinating enzyme]]
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[[Category: Deubiquitinating enzyme]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: linkage specificity]]
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[[Category: Linkage specificity]]
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[[Category: lys63- linked]]
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[[Category: Lys63- linked]]
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[[Category: nf-kb]]
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[[Category: Nf-kb]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: thiol protease]]
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[[Category: Thiol protease]]
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[[Category: ubiquitin]]
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[[Category: Ubiquitin]]
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[[Category: ubl conjugation pathway]]
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[[Category: Ubl conjugation pathway]]
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[[Category: usp domain]]
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[[Category: Usp domain]]
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[[Category: zn-binding domain]]
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[[Category: Zn-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:48:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:21 2008''
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Revision as of 15:48, 4 May 2008

Image:2vhf.jpg

Template:STRUCTURE 2vhf

STRUCTURE OF THE CYLD USP DOMAIN


Overview

The tumor suppressor CYLD antagonizes NF-kappaB and JNK signaling by disassembly of Lys63-linked ubiquitin chains synthesized in response to cytokine stimulation. Here we describe the crystal structure of the CYLD USP domain, revealing a distinctive architecture that provides molecular insights into its specificity toward Lys63-linked polyubiquitin. We identify regions of the USP domain responsible for this specificity and demonstrate endodeubiquitinase activity toward such chains. Pathogenic truncations of the CYLD C terminus, associated with the hypertrophic skin tumor cylindromatosis, disrupt the USP domain, accounting for loss of CYLD catalytic activity. A small zinc-binding B box domain, similar in structure to other crossbrace Zn-binding folds-including the RING domain found in E3 ubiquitin ligases-is inserted within the globular core of the USP domain. Biochemical and functional characterization of the B box suggests a role as a protein-interaction module that contributes to determining the subcellular localization of CYLD.

About this Structure

2VHF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module., Komander D, Lord CJ, Scheel H, Swift S, Hofmann K, Ashworth A, Barford D, Mol Cell. 2008 Feb 29;29(4):451-64. PMID:18313383 Page seeded by OCA on Sun May 4 18:48:53 2008

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OCA

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