2viu

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[[Image:2viu.gif|left|200px]]
[[Image:2viu.gif|left|200px]]
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{{Structure
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|PDB= 2viu |SIZE=350|CAPTION= <scene name='initialview01'>2viu</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2viu", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2viu| PDB=2viu | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2viu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2viu OCA], [http://www.ebi.ac.uk/pdbsum/2viu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2viu RCSB]</span>
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}}
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'''INFLUENZA VIRUS HEMAGGLUTININ'''
'''INFLUENZA VIRUS HEMAGGLUTININ'''
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[[Category: Skehel, J J.]]
[[Category: Skehel, J J.]]
[[Category: Wharton, S A.]]
[[Category: Wharton, S A.]]
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[[Category: envelope protein]]
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[[Category: Envelope protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hemagglutinin]]
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[[Category: Hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:53:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:50 2008''
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Revision as of 15:53, 4 May 2008

Image:2viu.gif

Template:STRUCTURE 2viu

INFLUENZA VIRUS HEMAGGLUTININ


Overview

The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

About this Structure

2VIU is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.

Reference

Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077 Page seeded by OCA on Sun May 4 18:53:48 2008

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OCA

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