2vit

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[[Image:2vit.gif|left|200px]]
[[Image:2vit.gif|left|200px]]
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{{Structure
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|PDB= 2vit |SIZE=350|CAPTION= <scene name='initialview01'>2vit</scene>, resolution 3.25&Aring;
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The line below this paragraph, containing "STRUCTURE_2vit", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_2vit| PDB=2vit | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vit OCA], [http://www.ebi.ac.uk/pdbsum/2vit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vit RCSB]</span>
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'''INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY'''
'''INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY'''
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[[Category: Skehel, J J.]]
[[Category: Skehel, J J.]]
[[Category: Wharton, S A.]]
[[Category: Wharton, S A.]]
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[[Category: complex (hemagglutinin/immmunoglobulin)]]
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[[Category: Glycoprotein]]
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[[Category: glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:53:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:53 2008''
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Revision as of 15:53, 4 May 2008

Image:2vit.gif

Template:STRUCTURE 2vit

INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY


Overview

The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

About this Structure

2VIT is a Protein complex structure of sequences from Mus musculus and Unidentified influenza virus. Full crystallographic information is available from OCA.

Reference

Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077 Page seeded by OCA on Sun May 4 18:53:44 2008

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