2p5z

<StructureSection load='2p5z' size='340' side='right' caption='[[2p5z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[2p5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o6 Escherichia coli o6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P5Z FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">c3393 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=217992 Escherichia coli O6])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5z OCA], [http://pdbe.org/2p5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p5z RCSB], [http://www.ebi.ac.uk/pdbsum/2p5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p5z ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2p5z TOPSAN]</span></td></tr>

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== Publication Abstract from PubMed ==

Protein secretion is a common property of pathogenic microbes. Gram-negative bacterial pathogens use at least 6 distinct extracellular protein secretion systems to export proteins through their multilayered cell envelope and in some cases into host cells. Among the most widespread is the newly recognized Type VI secretion system (T6SS) which is composed of 15-20 proteins whose biochemical functions are not well understood. Using crystallographic, biochemical, and bioinformatic analyses, we identified 3 T6SS components, which are homologous to bacteriophage tail proteins. These include the tail tube protein; the membrane-penetrating needle, situated at the distal end of the tube; and another protein associated with the needle and tube. We propose that T6SS is a multicomponent structure whose extracellular part resembles both structurally and functionally a bacteriophage tail, an efficient machine that translocates proteins and DNA across lipid membranes into cells.

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.,Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4154-9. Epub 2009 Feb 27. PMID:19251641<ref>PMID:19251641</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2p5z" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Escherichia coli o6]]

[[Category: Almo, S C]]

[[Category: Bonanno, J B]]

[[Category: Burley, S K]]

[[Category: Freeman, J C]]

[[Category: Gheyi, T]]

[[Category: Lau, C]]

[[Category: Maletic, M]]

[[Category: Structural genomic]]

[[Category: Ramagopal, U A]]

[[Category: Sauder, J M]]

[[Category: Sridhar, V]]

[[Category: Toro, R]]

[[Category: Unknown function]]