2vm0
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| - | |DOMAIN= | + | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01040 globin]</span> |
|RELATEDENTRY=[[1azi|1AZI]], [[1dwr|1DWR]], [[1dwt|1DWT]], [[1gjn|1GJN]], [[1hrm|1HRM]], [[1npf|1NPF]], [[1npg|1NPG]], [[1nz2|1NZ2]], [[1nz3|1NZ3]], [[1rse|1RSE]], [[1yma|1YMA]], [[1ymb|1YMB]], [[2frf|2FRF]], [[2frj|2FRJ]], [[2frk|2FRK]], [[2in4|2IN4]], [[2v1e|2V1E]], [[2v1f|2V1F]], [[2v1g|2V1G]], [[2v1h|2V1H]], [[2v1i|2V1I]], [[2v1j|2V1J]], [[1bje|1BJE]], [[1dws|1DWS]], [[1hsy|1HSY]], [[1nz4|1NZ4]], [[1nz5|1NZ5]], [[1wla|1WLA]], [[1xch|1XCH]], [[1ymc|1YMC]], [[2fri|2FRI]], [[2v1k|2V1K]], [[2vlx|2VLX]], [[2vly|2VLY]], [[2vlz|2VLZ]] | |RELATEDENTRY=[[1azi|1AZI]], [[1dwr|1DWR]], [[1dwt|1DWT]], [[1gjn|1GJN]], [[1hrm|1HRM]], [[1npf|1NPF]], [[1npg|1NPG]], [[1nz2|1NZ2]], [[1nz3|1NZ3]], [[1rse|1RSE]], [[1yma|1YMA]], [[1ymb|1YMB]], [[2frf|2FRF]], [[2frj|2FRJ]], [[2frk|2FRK]], [[2in4|2IN4]], [[2v1e|2V1E]], [[2v1f|2V1F]], [[2v1g|2V1G]], [[2v1h|2V1H]], [[2v1i|2V1I]], [[2v1j|2V1J]], [[1bje|1BJE]], [[1dws|1DWS]], [[1hsy|1HSY]], [[1nz4|1NZ4]], [[1nz5|1NZ5]], [[1wla|1WLA]], [[1xch|1XCH]], [[1ymc|1YMC]], [[2fri|2FRI]], [[2v1k|2V1K]], [[2vlx|2VLX]], [[2vly|2VLY]], [[2vlz|2VLZ]] | ||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm0 OCA], [http://www.ebi.ac.uk/pdbsum/2vm0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vm0 RCSB]</span> | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm0 OCA], [http://www.ebi.ac.uk/pdbsum/2vm0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vm0 RCSB]</span> | ||
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[[Category: x-ray-induced-photoreduction]] | [[Category: x-ray-induced-photoreduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:32:33 2008'' |
Revision as of 08:32, 2 April 2008
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| , resolution 1.60Å | |||||||
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| Sites: | , , , , , , and | ||||||
| Ligands: | , , , , | ||||||
| Domains: | globin | ||||||
| Related: | 1AZI, 1DWR, 1DWT, 1GJN, 1HRM, 1NPF, 1NPG, 1NZ2, 1NZ3, 1RSE, 1YMA, 1YMB, 2FRF, 2FRJ, 2FRK, 2IN4, 2V1E, 2V1F, 2V1G, 2V1H, 2V1I, 2V1J, 1BJE, 1DWS, 1HSY, 1NZ4, 1NZ5, 1WLA, 1XCH, 1YMC, 2FRI, 2V1K, 2VLX, 2VLY, 2VLZ
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF RADIATION-INDUCED MYOGLOBIN COMPOUND II GENERATED AFTER ANNEALING OF PEROXYMYOGLOBIN
Overview
The biological conversions of O(2) and peroxides to water as well as certain incorporations of oxygen atoms into small organic molecules can be catalyzed by metal ions in different clusters or cofactors. The catalytic cycle of these reactions passes through similar metal-based complexes in which one oxygen- or peroxide-derived oxygen atom is coordinated to an oxidized form of the catalytic metal center. In haem-based peroxidases or oxygenases the ferryl (Fe(IV)O) form is important in compound I and compound II, which are two and one oxidation equivalents higher than the ferric (Fe(III)) form, respectively. In this study we report the 1.35 A structure of a compound II model protein, obtained by reacting hydrogen peroxide with ferric myoglobin at pH 5.2. The molecular geometry is virtually unchanged compared to the ferric form, indicating that these reactive intermediates do not undergo large structural changes. It is further suggested that at low pH the dominating compound II resonance form is a hydroxyl radical ferric iron rather than an oxo-ferryl form, based on the short hydrogen bonding to the distal histidine (2.70 A) and the Fe...O distance. The 1.92 A Fe...O distance is in agreement with an EXAFS study of compound II in horseradish peroxidase.
About this Structure
2VM0 is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.
Reference
An iron hydroxide moiety in the 1.35 A resolution structure of hydrogen peroxide derived myoglobin compound II at pH 5.2., Hersleth HP, Dalhus B, Gorbitz CH, Andersson KK, J Biol Inorg Chem. 2002 Mar;7(3):299-304. Epub 2001 Oct 11. PMID:11935353
Page seeded by OCA on Wed Apr 2 11:32:33 2008
Categories: Equus caballus | Single protein | Andersson, K K. | Gorbitz, C H. | Hersleth, H P. | Ferryl | Haem | Heme | Iron | Metal-binding | Monooxygenase | Muscle protein | Oxygen activation | Oxygen transport | Peroxidase | Radiolytic- reduction | Reaction intermediate | Transport | X-ray-induced-photoreduction
