2vo1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2vo1.jpg|left|200px]]
[[Image:2vo1.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2vo1 |SIZE=350|CAPTION= <scene name='initialview01'>2vo1</scene>, resolution 2.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_2vo1", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+So4+A+1273'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+So4+A+1274'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+So4+A+1275'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+So4+B+1273'>AC4</scene> and <scene name='pdbsite=AC5:Binding+Site+For+Residue+So4+B+1274'>AC5</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2vo1| PDB=2vo1 | SCENE= }}
-
|RELATEDENTRY=[[2c5m|2C5M]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vo1 OCA], [http://www.ebi.ac.uk/pdbsum/2vo1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vo1 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''
'''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
2VO1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 2C5M. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO1 OCA].
+
2VO1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2c5m 2c5m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO1 OCA].
==Reference==
==Reference==
Line 49: Line 46:
[[Category: Thorsell, A G.]]
[[Category: Thorsell, A G.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
-
[[Category: amidotransferase]]
+
[[Category: Amidotransferase]]
-
[[Category: ctp]]
+
[[Category: Ctp]]
-
[[Category: ctp synthase]]
+
[[Category: Ctp synthase]]
-
[[Category: ctp synthetase]]
+
[[Category: Ctp synthetase]]
-
[[Category: ctp]]
+
[[Category: Ctp]]
-
[[Category: cytidine 5-prime triphosphate synthetase]]
+
[[Category: Cytidine 5-prime triphosphate synthetase]]
-
[[Category: glutamine]]
+
[[Category: Glutamine]]
-
[[Category: glutamine amidotransferase]]
+
[[Category: Glutamine amidotransferase]]
-
[[Category: ligase]]
+
[[Category: Ligase]]
-
[[Category: phosphoprotein]]
+
[[Category: Phosphoprotein]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: pyrimidine biosynthesis]]
+
[[Category: Pyrimidine biosynthesis]]
-
[[Category: utp]]
+
[[Category: Utp]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:04:03 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:47 2008''
+

Revision as of 16:04, 4 May 2008

Image:2vo1.jpg

Template:STRUCTURE 2vo1

CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE


Overview

Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is formed by three different subunits. Sulfate ions bound to the active sites indicate the positions of phosphate-binding sites for the substrates ATP and UTP and the feedback inhibitor CTP. Together with earlier structures of bacterial CTPS, the human CTPS structure provides an extended understanding of the structure-function relationship of CTPS-family members. The structure also serves as a basis for structure-based design of anti-proliferative inhibitors.

About this Structure

2VO1 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2c5m. Full crystallographic information is available from OCA.

Reference

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:16820675 Page seeded by OCA on Sun May 4 19:04:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vo1"
Personal tools