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3dzg

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==Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex==
==Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex==
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<StructureSection load='3dzg' size='340' side='right' caption='[[3dzg]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='3dzg' size='340' side='right'caption='[[3dzg]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dzg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DZG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dzg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=RF5:2-DEOXY-2-FLUORO-5-O-PHOSPHONO-ALPHA-D-ARABINOFURANOSE'>RF5</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=RF5:2-DEOXY-2-FLUORO-5-O-PHOSPHONO-ALPHA-D-ARABINOFURANOSE'>RF5</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dzf|3dzf]], [[3dzh|3dzh]], [[3dzi|3dzi]], [[3dzj|3dzj]], [[3dzk|3dzk]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dzf|3dzf]], [[3dzh|3dzh]], [[3dzi|3dzi]], [[3dzj|3dzj]], [[3dzk|3dzk]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzg OCA], [http://pdbe.org/3dzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dzg RCSB], [http://www.ebi.ac.uk/pdbsum/3dzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzg OCA], [https://pdbe.org/3dzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dzg RCSB], [https://www.ebi.ac.uk/pdbsum/3dzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Graeff, R]]
[[Category: Graeff, R]]
[[Category: Hao, Q]]
[[Category: Hao, Q]]

Revision as of 19:31, 20 October 2021

Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex

PDB ID 3dzg

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