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3db6

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==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902==
==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902==
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<StructureSection load='3db6' size='340' side='right' caption='[[3db6]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='3db6' size='340' side='right'caption='[[3db6]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3db6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DB6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3db6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DB6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FRS:1-[5-METHYL-2-(TRIFLUOROMETHYL)FURAN-3-YL]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-TRIAZOL-3-YLAMINO)PYRIMIDIN-4-YL]AMINO}ETHYL)-1,3-THIAZOL-2(3H)-YLIDENE]UREA'>FRS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRS:1-[5-METHYL-2-(TRIFLUOROMETHYL)FURAN-3-YL]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-TRIAZOL-3-YLAMINO)PYRIMIDIN-4-YL]AMINO}ETHYL)-1,3-THIAZOL-2(3H)-YLIDENE]UREA'>FRS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d5u|3d5u]], [[3d5w|3d5w]], [[3d5x|3d5x]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d5u|3d5u]], [[3d5w|3d5w]], [[3d5x|3d5x]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">plk1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">plk1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3db6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3db6 OCA], [http://pdbe.org/3db6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3db6 RCSB], [http://www.ebi.ac.uk/pdbsum/3db6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3db6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3db6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3db6 OCA], [https://pdbe.org/3db6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3db6 RCSB], [https://www.ebi.ac.uk/pdbsum/3db6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3db6 ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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==See Also==
==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Brachidanio rerio]]
[[Category: Brachidanio rerio]]
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[[Category: Large Structures]]
[[Category: Polo kinase]]
[[Category: Polo kinase]]
[[Category: Barr, K J]]
[[Category: Barr, K J]]

Revision as of 19:21, 20 October 2021

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902

PDB ID 3db6

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