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Function

Burkholderia species produce oxalate which helps maintain environmental pH. Two enzymes are required to produce oxalate, ObcA and ObcB. ObcA catalyzes first, resulting in a tetrahedral C6-CoA adduct from acetyl-CoA and oxaloacetate. ObcB then produces three products from the C6-CoA adduct which include oxalate, acetoacetate, and CoA. In Burkholderia thailandensis and Burkholderia pseudomallei Obc1 carries out both steps of this reaction as it is a single bi-functional enzyme.

Disease

Burkholderia species have many pathogenic consequences for plants and humans. B. cepacia effects immunocompromised individuals that may have cystic fibrosis or chronic granulomatous disease. B. pseudomallei causes a lethal infection called melioidosis that results in formation of abscesses. In plants, B. glumae causes bacterial panicle blight in rice.

Relevance

Understanding the reaction that is catalyzed by ObcA and ObcB in two steps and Obc1 in one step has clinical relevance. Currently, the molecular basis of the Obc enzymes is unknown. By studying these enzymes, a treatment may be developed for disease control that is caused by Obc enzymes.

Structural highlights

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