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Function

Two enzymes are responsible for the oxalate that is produced in the Burkholderia species. The first enzyme, ObcA, catalyzes the formation of a tetrahedral C6-CoA adduct from the substrates acetyl-COA and oxaloacetate. The second enzyme, ObcB, produces three products from the C6-CoA adduct. These products are oxalate, acetoacetate and CoA. The oxalate produced from the Burkholderia species, is necessary for bacterial growth and maintaining environmental pH.

Disease

Species of Burkholderia can be involved in plant or human pathogenesis. Several diseases, such as B. Glumae which causes bacterial panicle blight in rice, or B. cepacia, which is an opportunistic pathogen in immunocompromised individuals, like those with cystic fibrosis or chronic granulomatous disease. It can also be involved with B. pseudomallei which can cause meliondosis, a lethal infection that leads to the formation of abscesses in internal organs.

Relevance

By studying the two mono-functional enzymes, ObcA and ObcB, there is a better understanding of the underlying molecular basis. A bifunctional enzyme, Obc 1, can be used here for oxalogenesis. Researching and finding out more about these enzymes can help advance knowledge and potentially develop ways to control diseases associated with the Burkholderia species.

Structural highlights

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