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Sandbox Reserved 1458

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Revision as of 21:03, 16 November 2018

This Sandbox is Reserved from October 22, 2018 through April 30, 2019 for use in the course Biochemistry taught by Bonnie Hall at the Grand View University, Des Moines, IA USA. This reservation includes Sandbox Reserved 1456 through Sandbox Reserved 1470.

To get started:

Click the edit this page tab at the top. Save the page after each step, then edit it again.
Click the 3D button (when editing, above the wikitext box) to insert Jmol.
show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

PLpro

This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

1 Function
2 Disease
3 Relevance
4 Structural highlights

Function

The organism PLpro is from is Coronaviruses. IBV PLpro performs deubiquitination with catalytic efficiencies that are different from other PLpros. Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. The substrates and products are PLpro and ubiquitin.

Disease

A disease associated with the protein is avian infectious bronchitis in poultry. The protein helps out with scuttling antiviral responses and when this protein is working it stops the host(chicken) from being able to keep the virus from replicating. Other diseases associated with PLpro include respiratory tract infections and uro-gential tract infections.

Relevance

The results can be used to develop antivirals for the chickens and help save economic loss every year in the poultry industry.

Structural highlights

Here is a cartoon view of PLpro, it's main secondary features are In this cartoon view the most important tertiary and quaternary structures of PLpro are highlighted This is a space filling view of PLpro and it provides a view Here is a hydrophobicity-focused view of PLpro, the importance of hydrophobic and hydrophillic regions are that they Here is a view of the ligand. The important chemical features of the ligand are This is the catalytic triad and it helps the protein achieve its function by The active site is pictured here and has the key amino acids highlighted. Those key amino acids are . h This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

Kong, L., et al. “Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus.” Journal of Biological Chemistry, vol. 290, no. 11, 13 Mar. 2015, pp. 7160–7168.,

↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1458"

@@ Line 6: / Line 6: @@
 == Function ==
-The organism PLpro is from is Coronaviruses. IBV PLpro performs deubiquitination with catalytic efficiencies that are different from other PLpros. Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. The substrates and products are
+The organism PLpro is from is Coronaviruses. IBV PLpro performs deubiquitination with catalytic efficiencies that are different from other PLpros. Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. The substrates and products are PLpro and ubiquitin.
 == Disease ==
-A disease associated with the <scene name='79/799586/4x2z1/3'>PLpro</scene> protein is avian infectious bronchitis in poultry, The protein helps out with scuttling antiviral responses and when this protein is working it stops the host(chicken) from being able to keep the virus from replicating.
+A disease associated with the <scene name='79/799586/4x2z1/3'>PLpro</scene> protein is avian infectious bronchitis in poultry. The protein helps out with scuttling antiviral responses and when this protein is working it stops the host(chicken) from being able to keep the virus from replicating. Other diseases associated with PLpro include respiratory tract infections and uro-gential tract infections.

Sandbox Reserved 1458

From Proteopedia

Revision as of 21:03, 16 November 2018

PLpro

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Function

Disease

Relevance

Structural highlights

References

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