Colony-stimulating factor
From Proteopedia
(Difference between revisions)
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The structure of the complex between M-CSF and its receptor shows that a <scene name='80/801266/Cv/3'>dimer of M-CSF binds to 2 molecules of the receptor</scene>. There are <scene name='80/801266/Cv/5'>two binding sites between the molecules designated site I and site II</scene><ref>PMID:26235028</ref>. <scene name='80/801266/Cv/4'>All interactions</scene>. | The structure of the complex between M-CSF and its receptor shows that a <scene name='80/801266/Cv/3'>dimer of M-CSF binds to 2 molecules of the receptor</scene>. There are <scene name='80/801266/Cv/5'>two binding sites between the molecules designated site I and site II</scene><ref>PMID:26235028</ref>. <scene name='80/801266/Cv/4'>All interactions</scene>. | ||
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| + | ==3D structures of colony-stimulating factor== | ||
| + | [[Colony-stimulating factor 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[2gmf]], [[3uf2]] - hM-CSF - human<br /> | **[[2gmf]], [[3uf2]] - hM-CSF - human<br /> | ||
**[[5lxf]] - hM-CSF (mutant)<br /> | **[[5lxf]] - hM-CSF (mutant)<br /> | ||
| - | **[[4adq]], [[4adf]] - hM-CSF + BARF1<br /> | + | **[[4adq]], [[4adf]], [[4fa8]] - hM-CSF + BARF1<br /> |
**[[3uez]] - hM-CSF (mutant) + BARF1<br /> | **[[3uez]] - hM-CSF (mutant) + BARF1<br /> | ||
**[[4wrm]], [[4wrl]] - hM-CSF + CSF receptor<br /> | **[[4wrm]], [[4wrl]] - hM-CSF + CSF receptor<br /> | ||
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*Granulocyte colony stimulating factor | *Granulocyte colony stimulating factor | ||
| - | **[[1bgc]] - G-CSF - bovine<br /> | ||
| - | **[[1bgd]], [[1bge]] - G-CSF - dog<br /> | ||
**[[1rhg]] - hG-CSF <br /> | **[[1rhg]] - hG-CSF <br /> | ||
**[[1gnc]] - hG-CSF - NMR<br /> | **[[1gnc]] - hG-CSF - NMR<br /> | ||
| - | **[[5gw9]] - hG-CSF (mutant)<br /> | + | **[[5gw9]], [[5zo6]] - hG-CSF (mutant)<br /> |
**[[2d9q]], [[1pgr]], [[1cd9]] - hG-CSF + CSF receptor<br /> | **[[2d9q]], [[1pgr]], [[1cd9]] - hG-CSF + CSF receptor<br /> | ||
| + | **[[1bgc]] - G-CSF - bovine<br /> | ||
| + | **[[1bgd]], [[1bge]] - G-CSF - dog<br /> | ||
**[[1gcf]], [[1cto]] - mG-CSF C-terminal of LBD - NMR<br /> | **[[1gcf]], [[1cto]] - mG-CSF C-terminal of LBD - NMR<br /> | ||
}} | }} | ||
Revision as of 09:55, 14 May 2019
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3D structures of colony-stimulating factor
Updated on 14-May-2019
References
- ↑ Nemunaitis J. A comparative review of colony-stimulating factors. Drugs. 1997 Nov;54(5):709-29. doi: 10.2165/00003495-199754050-00004. PMID:9360058 doi:http://dx.doi.org/10.2165/00003495-199754050-00004
- ↑ Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017. PMID:16474424 doi:http://dx.doi.org/10.1038/sj.cr.7310017
- ↑ Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356. PMID:18551128 doi:http://dx.doi.org/10.1038/nri2356
- ↑ Metcalf D. The colony-stimulating factors and cancer. Nat Rev Cancer. 2010 Jun;10(6):425-34. doi: 10.1038/nrc2843. PMID:20495576 doi:http://dx.doi.org/10.1038/nrc2843
- ↑ Schneider A, Kuhn HG, Schabitz WR. A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle. 2005 Dec;4(12):1753-7. doi: 10.4161/cc.4.12.2213. Epub 2005 Dec 27. PMID:16258290 doi:http://dx.doi.org/10.4161/cc.4.12.2213
- ↑ Lieschke GJ, Burgess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N Engl J Med. 1992 Jul 2;327(1):28-35. doi: 10.1056/NEJM199207023270106. PMID:1375975 doi:http://dx.doi.org/10.1056/NEJM199207023270106
- ↑ Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:http://dx.doi.org/10.1016/j.str.2015.06.019
