Synaptosomal-associated protein

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<StructureSection load='3hd7' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='3hd7' size='340' side='right' caption='RAT neuronal SNARE complex containing SNAP25 N-terminal SNARE motif (gold), SNAP25 C-terminal SNARE motif (red), syntaxin-1a SNARE motif (cyan), VAMP2 SNARE motif (magenta), glycylglycylglycine and sulfate (PDB code [[3hd7]])' scene=''>
== Function ==
== Function ==
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**[[6mdo]], [[6dmp]] – rSNAP25 + vesicle fusing ATPase – rat – cryo EM<br />
**[[6mdo]], [[6dmp]] – rSNAP25 + vesicle fusing ATPase – rat – cryo EM<br />
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**[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rSNAP25 + vesicle fusing ATPase + VAMP2 + rSyntaxin 1a SNARE motif + a-soluble NSF attachment protein – cryo EM<br />
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**[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rSNAP25 + vesicle fusing ATPase + VAMP2 + rSyntaxin 1a SNARE motif + α-soluble NSF attachment protein – cryo EM<br />
**[[1xtg]] – hSNAP25 C-terminal SNARE motif – human<br />
**[[1xtg]] – hSNAP25 C-terminal SNARE motif – human<br />
**[[3dda]], [[3ddb]] – hSNAP25 C-terminal SNARE motif + botulinum neurotoxin<br />
**[[3dda]], [[3ddb]] – hSNAP25 C-terminal SNARE motif + botulinum neurotoxin<br />

Revision as of 11:25, 29 November 2018

RAT neuronal SNARE complex containing SNAP25 N-terminal SNARE motif (gold), SNAP25 C-terminal SNARE motif (red), syntaxin-1a SNARE motif (cyan), VAMP2 SNARE motif (magenta), glycylglycylglycine and sulfate (PDB code 3hd7)

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3D structures of synaptosomal-associated protein

Updated on 29-November-2018

Updated on 29-November-2018 {{#tree:id=OrganizedByTopic|openlevels=0|


References

  1. Noor A, Zahid S. A review of the role of synaptosomal-associated protein 25 (SNAP-25) in neurological disorders. Int J Neurosci. 2017 Sep;127(9):805-811. doi: 10.1080/00207454.2016.1248240. Epub, 2016 Nov 1. PMID:27734716 doi:http://dx.doi.org/10.1080/00207454.2016.1248240
  2. Greber S, Lubec G, Cairns N, Fountoulakis M. Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease. Electrophoresis. 1999 Apr-May;20(4-5):928-34. doi:, 10.1002/(SICI)1522-2683(19990101)20:4/5<928::AID-ELPS928>3.0.CO;2-Z. PMID:10344268 doi:<928::AID-ELPS928>3.0.CO;2-Z http://dx.doi.org/10.1002/(SICI)1522-2683(19990101)20:4/5<928::AID-ELPS928>3.0.CO;2-Z
  3. Wang L, Bittner MA, Axelrod D, Holz RW. The structural and functional implications of linked SNARE motifs in SNAP25. Mol Biol Cell. 2008 Sep;19(9):3944-55. doi: 10.1091/mbc.e08-04-0344. Epub 2008, Jul 2. PMID:18596234 doi:http://dx.doi.org/10.1091/mbc.e08-04-0344

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Michal Harel

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