6i5g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)in complex with 15d-PGJ2== | |
| - | + | <StructureSection load='6i5g' size='340' side='right'caption='[[6i5g]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6i5g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I5G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PTG:(5E,14E)-11-OXOPROSTA-5,9,12,14-TETRAEN-1-OIC+ACID'>PTG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5g OCA], [http://pdbe.org/6i5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i5g RCSB], [http://www.ebi.ac.uk/pdbsum/6i5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5g ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abis, G]] | ||
| + | [[Category: Conte, M R]] | ||
[[Category: Kopec, J]] | [[Category: Kopec, J]] | ||
| - | [[Category: | + | [[Category: Yue, W W]] |
| + | [[Category: 15d-pgj2]] | ||
| + | [[Category: Alpha_beta hydrolase fold]] | ||
| + | [[Category: Apoprotein]] | ||
| + | [[Category: Hseh ctd]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 06:09, 29 May 2019
X-ray structure of human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)in complex with 15d-PGJ2
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