This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6ijf
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the type VI effector-immunity complex (Tae4-Tai4) from Agrobacterium tumefaciens== | |
| + | <StructureSection load='6ijf' size='340' side='right' caption='[[6ijf]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ijf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IJF FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ijf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ijf OCA], [http://pdbe.org/6ijf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ijf RCSB], [http://www.ebi.ac.uk/pdbsum/6ijf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ijf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The type VI secretion system (T6SS) comprises needle-shaped multisubunit complexes that play a role in the microbial defense systems of Gram-negative bacteria. Some Gram-negative bacteria harboring a T6SS deliver toxic effector proteins into the cytoplasm or periplasm of competing bacteria in order to lyse and kill them. To avoid self-cell disruption, these bacteria have cognate immunity proteins that inhibit their toxic effector proteins. T6SS amidase effector protein 4 (Tae4) and T6SS amidase immunity protein 4 (Tai4) are a representative of the toxic effector-immunity pairs of the T6SS. Here, the three-dimensional structures of Tai4 and the Tae4-Tai4 complex from Agrobacterium tumefaciens are reported at 1.55 and 1.9 A resolution, respectively. A structural comparison with other Tae4-Tai4 homologs revealed similarities and differences in the catalytic and inhibitory mechanisms among the Tae4 and Tai4 family proteins. | ||
| - | + | Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.,Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):810-816. doi:, 10.1107/S2053230X18016369. Epub 2018 Nov 30. PMID:30511676<ref>PMID:30511676</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 6ijf" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fukuhara, S]] | ||
[[Category: Ishii, R]] | [[Category: Ishii, R]] | ||
[[Category: Ishitani, R]] | [[Category: Ishitani, R]] | ||
[[Category: Nakane, T]] | [[Category: Nakane, T]] | ||
| + | [[Category: Nureki, O]] | ||
[[Category: Yamashita, K]] | [[Category: Yamashita, K]] | ||
| - | [[Category: | + | [[Category: Antitoxin]] |
| + | [[Category: Complex]] | ||
Revision as of 08:32, 19 December 2018
Crystal structure of the type VI effector-immunity complex (Tae4-Tai4) from Agrobacterium tumefaciens
| |||||||||||
Categories: Fukuhara, S | Ishii, R | Ishitani, R | Nakane, T | Nureki, O | Yamashita, K | Antitoxin | Complex
