6mx0

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'''Unreleased structure'''
 
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The entry 6mx0 is ON HOLD until Paper Publication
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==Crystal structure of human STING apoprotein (G230A, H232R, R293Q)==
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<StructureSection load='6mx0' size='340' side='right' caption='[[6mx0]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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Authors: Lesburg, C.A., Siu, T., Ho, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mx0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MX0 FirstGlance]. <br>
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Description: Crystal structure of human STING apoprotein (G230A, H232R, R293Q)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mx0 OCA], [http://pdbe.org/6mx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/6mx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mx0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ho, T]]
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[[Category: Lesburg, C A]]
[[Category: Siu, T]]
[[Category: Siu, T]]
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[[Category: Ho, T]]
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[[Category: Immune system]]
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[[Category: Lesburg, C.A]]
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[[Category: Innate immunity]]
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[[Category: Open conformation]]
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[[Category: Signaling]]

Revision as of 08:34, 19 December 2018

Crystal structure of human STING apoprotein (G230A, H232R, R293Q)

6mx0, resolution 1.73Å

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