6myf
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of free human Scribble PDZ1 domain== | |
| - | + | <StructureSection load='6myf' size='340' side='right'caption='[[6myf]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6myf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6myf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6myf OCA], [http://pdbe.org/6myf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6myf RCSB], [http://www.ebi.ac.uk/pdbsum/6myf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6myf ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fuentes, E J]] | ||
[[Category: Gakhar, L]] | [[Category: Gakhar, L]] | ||
[[Category: Hou, T]] | [[Category: Hou, T]] | ||
| - | [[Category: Sun, Y | + | [[Category: Sun, Y J]] |
| - | [[Category: | + | [[Category: Cell adhesion]] |
| + | [[Category: Pdz binding motif binding]] | ||
| + | [[Category: Peptide binding protein]] | ||
| + | [[Category: Tight junction]] | ||
Revision as of 07:27, 10 April 2019
Crystal structure of free human Scribble PDZ1 domain
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