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6ioz

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Current revision (09:48, 22 November 2023) (edit) (undo)
 
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==Structural insights of idursulfase beta==
==Structural insights of idursulfase beta==
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<StructureSection load='6ioz' size='340' side='right' caption='[[6ioz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='6ioz' size='340' side='right'caption='[[6ioz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ioz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IOZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ioz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IOZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALS:(3S)-3-(SULFOOXY)-L-SERINE'>ALS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALS:(3S)-3-(SULFOOXY)-L-SERINE'>ALS</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDS, SIDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ioz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioz OCA], [https://pdbe.org/6ioz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ioz RCSB], [https://www.ebi.ac.uk/pdbsum/6ioz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioz ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iduronate-2-sulfatase Iduronate-2-sulfatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.13 3.1.6.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ioz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioz OCA], [http://pdbe.org/6ioz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ioz RCSB], [http://www.ebi.ac.uk/pdbsum/6ioz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioz ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Mucopolysaccharidosis type 2, attenuated form;Mucopolysaccharidosis type 2, severe form. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN] Mucopolysaccharidosis type 2, attenuated form;Mucopolysaccharidosis type 2, severe form. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
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[https://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN] Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
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==See Also==
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*[[Sulfatase 3D structures|Sulfatase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Iduronate-2-sulfatase]]
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[[Category: Large Structures]]
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[[Category: Hong, J]]
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[[Category: Hong J]]
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[[Category: Kim, D]]
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[[Category: Kim D]]
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[[Category: Kim, H]]
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[[Category: Kim H]]
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[[Category: Lee, K]]
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[[Category: Lee K]]
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[[Category: Oh, B H]]
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[[Category: Oh BH]]
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[[Category: Seo, J]]
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[[Category: Seo J]]
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[[Category: Alpha-l-iduronate sulfate sulfatase]]
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[[Category: Hydrolase]]
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[[Category: Iduronate 2-sulfatase 14kda chain]]
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[[Category: Iduronate 2-sulfatase 42kda chain]]
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[[Category: Idursulfase beta]]
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Current revision

Structural insights of idursulfase beta

PDB ID 6ioz

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