3f0t

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==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==
==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==
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<StructureSection load='3f0t' size='340' side='right' caption='[[3f0t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3f0t' size='340' side='right'caption='[[3f0t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F0T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2p|1e2p]], [[1e2h|1e2h]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e2p|1e2p]], [[1e2h|1e2h]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [http://pdbe.org/3f0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [http://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [https://pdbe.org/3f0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [https://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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[[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Hhv-1]]
[[Category: Hhv-1]]
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[[Category: Large Structures]]
[[Category: Thymidine kinase]]
[[Category: Thymidine kinase]]
[[Category: Ametamey, S]]
[[Category: Ametamey, S]]

Revision as of 09:21, 23 February 2022

Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

PDB ID 3f0t

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