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3edi
From Proteopedia
(Difference between revisions)
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==Crystal structure of tolloid-like protease 1 (TLL-1) protease domain== | ==Crystal structure of tolloid-like protease 1 (TLL-1) protease domain== | ||
| - | <StructureSection load='3edi' size='340' side='right' caption='[[3edi]], [[Resolution|resolution]] 1.40Å' scene=''> | + | <StructureSection load='3edi' size='340' side='right'caption='[[3edi]], [[Resolution|resolution]] 1.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3edi]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3edi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDI FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3edg|3edg]], [[3edh|3edh]], [[1dle|1dle]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3edg|3edg]], [[3edh|3edh]], [[1dle|1dle]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLL1, TLL ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLL1, TLL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edi OCA], [https://pdbe.org/3edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edi RCSB], [https://www.ebi.ac.uk/pdbsum/3edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edi ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TLL1_HUMAN TLL1_HUMAN]] Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6) [MIM:[https://omim.org/entry/613087 613087]]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.<ref>PMID:18830233</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TLL1_HUMAN TLL1_HUMAN]] Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sweeney, A Mac]] | [[Category: Sweeney, A Mac]] | ||
[[Category: Alternative splicing]] | [[Category: Alternative splicing]] | ||
Revision as of 11:47, 16 February 2022
Crystal structure of tolloid-like protease 1 (TLL-1) protease domain
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