Sandbox Reserved 1475
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<Structure load='1BI9' size='350' frame='true' align='right' caption='Retinal Dehydrogenase Type Two with NAD bound (PDB entry [[1bi9]])' scene=" /> | <Structure load='1BI9' size='350' frame='true' align='right' caption='Retinal Dehydrogenase Type Two with NAD bound (PDB entry [[1bi9]])' scene=" /> | ||
| - | This molecular structure is Retinal Dehydrogenase Type Two (RalDH2). This enzyme is part of the super family Aldehyde Dehydrogenase. The function of this enzyme is to catalyze the oxidation of retinal to retinoic acid.<ref>PMID:10320326</ref> This is the last step in the formation of the hormone from Vitamin A (retinol). RalDH2 is expressed in ''Escherichia coli'' strain BL21(DE3) <ref>PMID:9761861</ref> | + | This molecular structure is Retinal Dehydrogenase Type Two (RalDH2). This enzyme is part of the super family Aldehyde Dehydrogenase. The function of this enzyme is to catalyze the oxidation of retinal to retinoic acid. Retinoic acid produces a putative morphogen that initiates pattern formation in the early embryo.<ref name="Lamb AL, Newcomber ME">PMID:10320326</ref> This is the last step in the formation of the hormone from Vitamin A (retinol). RalDH2 is expressed in ''Escherichia coli'' strain BL21(DE3) <ref name=Lamb Al, Wang X>PMID:9761861</ref> |
== Function == | == Function == | ||
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| + | The main function of this enzyme is to Retinoic acid. RalDH2 requires (NAD+) as a cofactor.<ref name="Lamb AL, Newcomber ME" /> In the oxidoreductase reaction, NAD+ acts as an electron acceptor. The reaction of this enzyme is [(retinal) + (NAD+) + (H2O) ↔ (retinoic acid) + (NADH) + (H+) ]. | ||
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== Disease == | == Disease == | ||
Revision as of 00:26, 5 December 2018
</StructureSection>
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Retinal Dehydrogenase Type Two Structure
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This molecular structure is Retinal Dehydrogenase Type Two (RalDH2). This enzyme is part of the super family Aldehyde Dehydrogenase. The function of this enzyme is to catalyze the oxidation of retinal to retinoic acid. Retinoic acid produces a putative morphogen that initiates pattern formation in the early embryo.[1] This is the last step in the formation of the hormone from Vitamin A (retinol). RalDH2 is expressed in Escherichia coli strain BL21(DE3) [2]
Function
The main function of this enzyme is to Retinoic acid. RalDH2 requires (NAD+) as a cofactor.[1] In the oxidoreductase reaction, NAD+ acts as an electron acceptor. The reaction of this enzyme is [(retinal) + (NAD+) + (H2O) ↔ (retinoic acid) + (NADH) + (H+) ].
Disease
Relevance
Structural highlights
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</StructureSection>
References
- ↑ 1.0 1.1 Lamb AL, Newcomer ME. The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity. Biochemistry. 1999 May 11;38(19):6003-11. PMID:10320326 doi:10.1021/bi9900471
- ↑ Lamb AL, Wang X, Napoli JL, Newcomer ME. Purification, crystallization and preliminary X-ray diffraction studies of retinal dehydrogenase type II. Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):639-42. PMID:9761861
