2zbd

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[[Image:2zbd.jpg|left|200px]]
[[Image:2zbd.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2zbd |SIZE=350|CAPTION= <scene name='initialview01'>2zbd</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2zbd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2zbd| PDB=2zbd | SCENE= }}
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|RELATEDENTRY=[[1su4|1SU4]], [[1iwo|1IWO]], [[1vfp|1VFP]], [[1wpg|1WPG]], [[2agv|2AGV]], [[2dqs|2DQS]], [[2ear|2EAR]], [[2eas|2EAS]], [[2eat|2EAT]], [[2eau|2EAU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zbd OCA], [http://www.ebi.ac.uk/pdbsum/2zbd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2zbd RCSB]</span>
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}}
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'''Crystal Structure of the SR Calcium Pump with Bound Aluminium Fluoride, ADP and Calcium'''
'''Crystal Structure of the SR Calcium Pump with Bound Aluminium Fluoride, ADP and Calcium'''
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==About this Structure==
==About this Structure==
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2ZBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entries 2Z9R and 1WPE. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBD OCA].
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2ZBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wpe 1wpe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBD OCA].
==Reference==
==Reference==
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[[Category: Toyoshima, C.]]
[[Category: Toyoshima, C.]]
[[Category: Tsuda, T.]]
[[Category: Tsuda, T.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: calcium transport]]
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[[Category: Calcium transport]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: had fold]]
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[[Category: Had fold]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: magnesium]]
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[[Category: Magnesium]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: sarcoplasmic reticulum]]
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[[Category: Sarcoplasmic reticulum]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:06:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:20:08 2008''
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Revision as of 17:06, 4 May 2008

Image:2zbd.jpg

Template:STRUCTURE 2zbd

Crystal Structure of the SR Calcium Pump with Bound Aluminium Fluoride, ADP and Calcium


Overview

P-type ion transporting ATPases are ATP-powered ion pumps that establish ion concentration gradients across biological membranes. Transfer of bound cations to the lumenal or extracellular side occurs while the ATPase is phosphorylated. Here we report at 2.3 A resolution the structure of the calcium-ATPase of skeletal muscle sarcoplasmic reticulum, a representative P-type ATPase that is crystallized in the absence of Ca2+ but in the presence of magnesium fluoride, a stable phosphate analogue. This and other crystal structures determined previously provide atomic models for all four principal states in the reaction cycle. These structures show that the three cytoplasmic domains rearrange to move six out of ten transmembrane helices, thereby changing the affinity of the Ca2+-binding sites and the gating of the ion pathway. Release of ADP triggers the opening of the lumenal gate and release of phosphate its closure, effected mainly through movement of the A-domain, the actuator of transmembrane gates.

About this Structure

2ZBD is a Single protein structure of sequence from Oryctolagus cuniculus. This structure supersedes the now removed PDB entries and 1wpe. Full crystallographic information is available from OCA.

Reference

Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues., Toyoshima C, Nomura H, Tsuda T, Nature. 2004 Nov 18;432(7015):361-8. Epub 2004 Sep 26. PMID:15448704 Page seeded by OCA on Sun May 4 20:06:46 2008

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