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6e5v

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Current revision (06:19, 11 October 2023) (edit) (undo)
 
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==human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)==
==human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)==
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<StructureSection load='6e5v' size='340' side='right' caption='[[6e5v]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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<StructureSection load='6e5v' size='340' side='right'caption='[[6e5v]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRM8, GPRC1H, MGLUR8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [http://pdbe.org/6e5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [http://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [https://pdbe.org/6e5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [https://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>
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[https://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6e5v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6e5v" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ashok, S]]
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[[Category: Large Structures]]
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[[Category: Atwell, S]]
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[[Category: Ashok S]]
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[[Category: Bures, M]]
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[[Category: Atwell S]]
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[[Category: Chen, Q]]
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[[Category: Bures M]]
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[[Category: Hao, J]]
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[[Category: Chen Q]]
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[[Category: Ho, J D]]
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[[Category: Hao J]]
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[[Category: Monn, J A]]
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[[Category: Ho JD]]
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[[Category: Schkeryantz, J M]]
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[[Category: Monn JA]]
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[[Category: Vargas, M C]]
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[[Category: Schkeryantz JM]]
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[[Category: Wang, J]]
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[[Category: Vargas MC]]
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[[Category: Dcpg]]
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[[Category: Wang J]]
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[[Category: Grm8]]
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[[Category: Mglur8 atd]]
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[[Category: Signaling protein]]
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Current revision

human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)

PDB ID 6e5v

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