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3fr4

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==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors==
==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors==
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<StructureSection load='3fr4' size='340' side='right' caption='[[3fr4]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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<StructureSection load='3fr4' size='340' side='right'caption='[[3fr4]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FR4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FR4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F8A:9-[2-(TRIFLUOROMETHYL)BENZYL]-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-8-CARBOXYLIC+ACID'>F8A</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F8A:9-[2-(TRIFLUOROMETHYL)BENZYL]-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-8-CARBOXYLIC+ACID'>F8A</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fr2|3fr2]], [[3fr5|3fr5]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fr2|3fr2]], [[3fr5|3fr5]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr4 OCA], [http://pdbe.org/3fr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fr4 RCSB], [http://www.ebi.ac.uk/pdbsum/3fr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr4 OCA], [https://pdbe.org/3fr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3fr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
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[[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Fatty acid-binding protein|Fatty acid-binding protein]]
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Axen, E]]
[[Category: Axen, E]]
[[Category: Barf, T]]
[[Category: Barf, T]]

Revision as of 08:08, 2 March 2022

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors

PDB ID 3fr4

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